Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Department of Gastroenterology, Cancer Institute Hospital, Tokyo, Japan.
Gut Liver. 2024 Jul 15;18(4):602-610. doi: 10.5009/gnl230354. Epub 2024 Feb 23.
BACKGROUND/AIMS: : Nutritional factors associated with gastric cancer (GC) are not completely understood. We aimed to determine the effect of nutrient intake on the incidence of GC.
: This was a analysis of a prospective trial that evaluated modalities for GC screening in participants aged 30 to 74 years living in high-risk areas for GC in Japan between June 2011 and March 2013. The patients were followed up for GC incidence for 6 years. All participants completed a self-administered food frequency questionnaire (FFQ) upon enrollment before GC screening. Daily nutrient intake was calculated from the FFQ and dichotomized at each cutoff value using receiver operating characteristic analysis. Risk factors associated with GC incidence were investigated in terms of nutrient intake and participant characteristics using Cox proportional hazards regression analysis.
: Overall, 1,147 participants were included in this analysis. The median age was 62 years, and 50.7% of the participants were men. The median follow-up period was 2,184 days. GC was detected in 25 participants during the follow-up. Multivariate Cox proportional hazards regression analysis revealed that the intake of sodium (adjusted hazards ratio [aHR], 3.905; 95% confidence interval [CI], 1.520 to 10.035; p=0.005) and vitamin D (aHR, 2.747; 95% CI, 1.111 to 6.788, p=0.029) were positively associated with GC incidence, whereas the intake of soluble dietary fiber (aHR, 0.104; 95% CI, 0.012 to 0.905; p=0.040) was inversely associated with GC incidence.
: Daily high intake of sodium and vitamin D and low soluble dietary fiber intake are associated with GC incidence.
背景/目的：与胃癌（GC）相关的营养因素尚未完全阐明。我们旨在确定营养素摄入对 GC 发病率的影响。
这是一项前瞻性研究的分析，该研究评估了 2011 年 6 月至 2013 年 3 月期间在日本高危地区年龄在 30 至 74 岁之间的参与者进行 GC 筛查的模式。患者随访了 6 年的 GC 发病率。所有参与者在 GC 筛查前完成了一份自我管理的食物频率问卷（FFQ）。根据 FFQ 计算每日营养素摄入量，并使用接收者操作特征分析将其在每个截止值处分为二分类。使用 Cox 比例风险回归分析，根据营养素摄入和参与者特征调查与 GC 发病率相关的危险因素。
总体而言，本分析纳入了 1147 名参与者。中位年龄为 62 岁，50.7%的参与者为男性。中位随访期为 2184 天。在随访期间发现 25 名参与者患有 GC。多变量 Cox 比例风险回归分析显示，钠的摄入量（调整后的风险比[aHR]，3.905；95%置信区间[CI]，1.520 至 10.035；p=0.005）和维生素 D（aHR，2.747；95%CI，1.111 至 6.788，p=0.029）与 GC 发病率呈正相关，而可溶性膳食纤维的摄入量（aHR，0.104；95%CI，0.012 至 0.905；p=0.040）与 GC 发病率呈负相关。
每日高钠和维生素 D 摄入以及低可溶性膳食纤维摄入与 GC 发病率相关。
