Bozzi Yuri, Borrelli Emiliana
Istituto di Neuroscienze del CNR, via Moruzzi 1, 56100 Pisa, Italy.
Trends Neurosci. 2006 Mar;29(3):167-74. doi: 10.1016/j.tins.2006.01.002. Epub 2006 Jan 27.
Accurate control of dopamine levels and/or the resulting dopamine-receptor interaction is essential for brain function. Indeed, several human neurological and psychiatric disorders are characterized by dysfunctions of the dopaminergic system. Dopamine has been reported to exert either protective or toxic effects on neurons, yet it is unclear whether these effects are receptor-dependent and, if so, which dopamine receptor could be involved. The D(2) dopamine receptor occupies a privileged position because its signalling might be neuroprotective in human diseases, such as Parkinson's disease, ischaemia and epilepsy. Unravelling the role of D(2) receptors in neuronal death and survival might be central to understanding the mechanisms that underlie several neuropathologies.
精确控制多巴胺水平和/或由此产生的多巴胺受体相互作用对于大脑功能至关重要。事实上，几种人类神经和精神疾病的特征是多巴胺能系统功能失调。据报道，多巴胺对神经元有保护或毒性作用，但尚不清楚这些作用是否依赖受体，如果是，可能涉及哪种多巴胺受体。D(2)多巴胺受体占据特殊地位，因为其信号传导在人类疾病如帕金森病、缺血和癫痫中可能具有神经保护作用。阐明D(2)受体在神经元死亡和存活中的作用可能是理解几种神经病理学潜在机制的核心。
