Kanda Atsuhiro, Minakata Hiroyuki
Suntory Institute for Bioorganic Research, 1-1-1 Wakayamadai, Shimamoto, Mishima, Osaka 618-8503, Japan.
Peptides. 2006 Jul;27(7):1755-61. doi: 10.1016/j.peptides.2005.12.006. Epub 2006 Jan 26.
A novel small cardioactive peptide (SCP)-related peptide (oct-SCPRP: Ser-Asn-Gly-Tyr-Leu-Ala-Leu-Pro-Arg-Gln-NH2) was isolated from the brain of the octopus (Octopus vulgaris). cDNA encoding this precursor protein was cloned. Oct-SCPRP was shown to evoke contraction in the radula protractor muscle, and the precursor protein was highly homologous to the SCP family in the Mollusk but did not encode a related peptide, SCPB. The expression of oct-SCPRP mRNA was present not only in the peripheral nervous system (PNS) which is a motor center for the control of feeding, but also in the central nervous system (CNS) which is capable of complex analysis, learning, and controls behaviors.
从普通章鱼（Octopus vulgaris）的大脑中分离出一种新型的小活性肽（SCP）相关肽（八肽-SCPRP：Ser-Asn-Gly-Tyr-Leu-Ala-Leu-Pro-Arg-Gln-NH2）。克隆了编码该前体蛋白的cDNA。八肽-SCPRP可引起齿舌牵引肌收缩，该前体蛋白与软体动物中的SCP家族高度同源，但不编码相关肽SCPB。八肽-SCPRP mRNA不仅存在于作为控制进食的运动中心的外周神经系统（PNS）中，还存在于能够进行复杂分析、学习并控制行为的中枢神经系统（CNS）中。
