生殖功能衰竭患者染色体异常的发生率。
The frequency of chromosomal abnormalities in patients with reproductive failure.
作者信息
Celep Figen, Karagüzel Ahmet, Ozeren Mehmet, Bozkaya Hasan
机构信息
Karadeniz Technical University, Faculty of Medicine, Department of Medical Biology and Genetics, Trabzon, Turkey.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2006 Jul;127(1):106-9. doi: 10.1016/j.ejogrb.2005.12.019. Epub 2006 Jan 27.
OBJECTIVE
To investigate the ratio of chromosomal abnormalities in recurrent fetal wastage.
STUDY DESIGN
We conducted a study of the cytogenetic data of 645 couples (1290 patients) with recurrent fetal wastage examined at the Department of Medical Biology and Genetics, Trabzon, Turkey. Couples who had first trimester miscarriages/abortion, preceded or followed by a second or third trimester fetal death/fetal abnormalities were recruited from Obstetrics and Gynecology Clinics for cytogenetics analysis.
RESULTS
Chromosome abnormalities were found in 25 (3.86%) patients. The chromosomal abnormalities were structural (3.71%) and numerical (0.15%). Polymorphisms of heterochromatin blocks and inv(9) were shown in 115 (17.51%) patients.
CONCLUSIONS
Chromosome analyses are an important and necessary part of the etiological research in couples with recurrent fetal wastage.
目的
研究复发性流产中染色体异常的比例。
研究设计
我们对在土耳其特拉布宗医学生物学与遗传学系接受检查的645对（1290名患者）复发性流产夫妇的细胞遗传学数据进行了研究。从妇产科诊所招募了在孕早期有流产史，且在孕中期或孕晚期有胎儿死亡/胎儿异常情况的夫妇，进行细胞遗传学分析。
结果
在25名（3.86%）患者中发现了染色体异常。染色体异常包括结构异常（3.71%）和数目异常（0.15%）。115名（17.51%）患者出现了异染色质块多态性和9号染色体倒位。
结论
染色体分析是复发性流产夫妇病因学研究的重要且必要的一部分。
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