对反复自然流产夫妇的细胞遗传学研究。
A cytogenetic study of couples with repeated spontaneous abortions.
作者信息
Niroumanesh Shirin, Mehdipour Parvin, Farajpour Ali, Darvish Soodabeh
机构信息
Mirza Koochak Khan Hospital, Medical Sciences/University of Tehran, Tehran, Iran.
出版信息
Ann Saudi Med. 2011 Jan-Feb;31(1):77-9. doi: 10.4103/0256-4947.75785.
BACKGROUND AND OBJECTIVE
The frequency of chromosomal aberrations in Iran is not definitely known. This study determined the frequency of chromosomal aberrations in a series of couples with two or more spontaneous abortions and compared the findings with that reported from other countries.
METHODS
This was a descriptive study conducted on 100 couples with recurrent abortions. Both partners were karyotyped as part of the primary investigation. Other probable causes of abortion were also investigated.
RESULTS
Chromosomal aberrations were found in 8 (8%) of the females and 5 (5%) of the males. The prevalence of chromosomal abnormalities was as follows: 4 (30.8%) balanced reciprocal translocations, 3 (23%) Robertsonian translocations, 3 (23%) pericentric inversions, 1 (7.7%) paracentric inversion, 1 (7.7%) chromosomal marker, and 1 (7.7%) polymorphism 9qh+.
CONCLUSIONS
The pattern of chromosomal aberrations was similar to that reported in other studies, but the prevalence of chromosomal aberrations was higher.
背景与目的
伊朗染色体畸变的发生率尚不确定。本研究确定了一系列有两次或更多次自然流产的夫妇中染色体畸变的发生率，并将结果与其他国家报告的情况进行比较。
方法
这是一项针对100对复发性流产夫妇的描述性研究。作为初步调查的一部分，对夫妇双方进行了核型分析。还调查了其他可能的流产原因。
结果
在8名女性（8%）和5名男性（5%）中发现了染色体畸变。染色体异常的发生率如下：4例（30.8%）平衡易位，3例（23%）罗伯逊易位，3例（23%）臂间倒位，1例（7.7%）臂内倒位，1例（7.7%）染色体标记，1例（7.7%）9qh+多态性。
结论
染色体畸变模式与其他研究报告的相似，但染色体畸变的发生率更高。
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