长期暴露于GSM 1800兆赫兹微波会降低培养的海马神经元中的兴奋性突触活动。

Chronic exposure to GSM 1800-MHz microwaves reduces excitatory synaptic activity in cultured hippocampal neurons.

作者信息

Xu Shujun, Ning Wei, Xu Zhengping, Zhou Suya, Chiang Huai, Luo Jianhong

机构信息

Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou 310031, China.

出版信息

Neurosci Lett. 2006 May 8;398(3):253-7. doi: 10.1016/j.neulet.2006.01.004. Epub 2006 Jan 27.

DOI:10.1016/j.neulet.2006.01.004

PMID:16443327

Abstract

The world wide proliferation of mobile phones raises the concern about the health effects of 1800-MHz microwaves on the brain. The present study assesses the effects of microwave exposure on the function of cultured hippocampal neurons of rats using whole cell patch-clamp analysis combined with immunocytochemistry. We showed that chronic exposure (15 min per day for 8 days) to Global System for Mobile Communication (GSM) 1800-MHz microwaves at specific absorption rate (SAR) of 2.4 W/kg induced a selective decrease in the amplitude of alpha-amino-3-hydroxy-5-methyl-4-soxazole propionic acid (AMPA) miniature excitatory postsynaptic currents (mEPSCs), whereas the frequency of AMPA mEPSCs and the amplitude of N-methyl-D-aspartate (NMDA) mEPSCs did not change. Furthermore, the GSM microwave treatment decreased the expression of postsynaptic density 95 (PSD95) in cultured neurons. Our results indicated that 2.4 W/kg GSM 1800-MHz microwaves may reduce excitatory synaptic activity and the number of excitatory synapses in cultured rat hippocampal neurons.

摘要

手机在全球范围内的普及引发了人们对1800兆赫兹微波对大脑健康影响的担忧。本研究采用全细胞膜片钳分析结合免疫细胞化学方法，评估微波暴露对大鼠培养海马神经元功能的影响。我们发现，以2.4瓦/千克的比吸收率（SAR）对全球移动通信系统（GSM）1800兆赫兹微波进行慢性暴露（每天15分钟，持续8天），会导致α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）微小兴奋性突触后电流（mEPSCs）的幅度选择性降低，而AMPA mEPSCs的频率和N-甲基-D-天冬氨酸（NMDA）mEPSCs的幅度没有变化。此外，GSM微波处理降低了培养神经元中突触后致密蛋白95（PSD95）的表达。我们的结果表明，2.4瓦/千克的GSM 1800兆赫兹微波可能会降低培养的大鼠海马神经元的兴奋性突触活动和兴奋性突触数量。