Air Force Research Laboratory, 711Th Human Performance Wing, Airman Systems Directorate, Bioeffects Division, Radio Frequency Bioeffects Branch, JBSA Fort Sam Houston, 4141 Petroleum Road, San Antonio, TX, 78234, USA.
General Dynamics Information Technology, JBSA Fort Sam Houston, 4141 Petroleum Road, San Antonio, TX, 78234, USA.
Sci Rep. 2022 Mar 3;12(1):3506. doi: 10.1038/s41598-022-06914-0.
Exposures to radiofrequency electromagnetic fields (RF-EMFs, 100 kHz to 6 GHz) have been associated with both positive and negative effects on cognitive behavior. To elucidate the mechanism of RF-EMF interaction, a few studies have examined its impact on neuronal activity and synaptic plasticity. However, there is still a need for additional basic research that further our understanding of the underlying mechanisms of RF-EMFs on the neuronal system. The present study investigated changes in neuronal activity and synaptic transmission following a 60-min exposure to 3.0 GHz RF-EMF at a low dose (specific absorption rate (SAR) < 1 W/kg). We showed that RF-EMF exposure decreased the amplitude of action potential (AP), depolarized neuronal resting membrane potential (MP), and increased neuronal excitability and synaptic transmission in cultured primary hippocampal neurons (PHNs). The results show that RF-EMF exposure can alter neuronal activity and highlight that more investigations should be performed to fully explore the RF-EMF effects and mechanisms.
射频电磁场（RF-EMF，100 kHz 至 6 GHz）暴露可对认知行为产生积极和消极影响。为了阐明 RF-EMF 相互作用的机制，一些研究已经研究了其对神经元活动和突触可塑性的影响。然而，仍需要进行更多的基础研究，以进一步了解 RF-EMF 对神经元系统的潜在机制。本研究在培养的原代海马神经元（PHN）中研究了暴露于 3.0 GHz RF-EMF 低剂量（比吸收率（SAR）< 1 W/kg）60 分钟后神经元活动和突触传递的变化。我们表明，RF-EMF 暴露会降低动作电位（AP）的幅度，使神经元静息膜电位（MP）去极化，并增加神经元兴奋性和突触传递。结果表明，RF-EMF 暴露可以改变神经元活动，并强调应进行更多的研究以充分探索 RF-EMF 的影响和机制。
