Kolovou Genovefa D, Anagnostopoulou Katherine K, Pavlidis Antonis N, Salpea Klelia D, Hoursalas Ioannis S, Manolis Athanasios, Cokkinos Dennis V
1st Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Ave, 17674 Athens, Greece.
Maturitas. 2006 Aug 20;55(1):19-26. doi: 10.1016/j.maturitas.2006.01.002. Epub 2006 Jan 26.
The metabolic syndrome (MetS) is associated with an increased incidence of coronary heart disease (CHD). Postprandial hypertriglyceridaemia is also associated with CHD. The aim of this study was to evaluate the postprandial lipaemia after an oral fat tolerance test (OFTT) in women with MetS.
OFTT, was given to 21 menopausal women with MetS (defined by the Adult Treatment Panel III) and to 12 healthy menopausal women. Triglyceride (TG) levels were measured before and 2, 4, 6 and 8h after the OFTT. The postprandial response was quantified by the areas under the curve (AUC) of TG levels. MetS women were subdivided according to body mass index (BMI) < or > or =30kg/m(2), and to fasting TG levels < or > or =150mg/dl.
The response to the OFTT was significantly higher in the MetS group compared to healthy [AUC(S.D.), in mg/dl/h; 2014(933) versus 732(197), p<0.001]. The subjects with BMI < or > or =30kg/m(2) had similar fasting TG levels [157(60)mg/dl versus 158(67) mg/dl] and AUC [1975(898) versus 2072(1044), respectively]. The MetS women with TG> or =150mg/dl had higher AUC compared to those with TG<150mg/dl [2502(854) versus 1281(441), p=0.002]. In linear regression analysis, where BMI, high-density lipoprotein cholesterol, fasting TG, HOMA-IR and QUICKI were the independent variables, only fasting TGs significantly predicted the AUC (coefficient B=11.866, p=0.008).
The fasting TG concentration is the main determinant of postprandial lipaemia. The obesity state was not an additional determinant for exaggerated postprandial response in MetS women. The abnormal postprandial lipaemia could be added as an important metabolic disturbance to the MetS.
代谢综合征（MetS）与冠心病（CHD）发病率增加相关。餐后高甘油三酯血症也与冠心病相关。本研究旨在评估代谢综合征女性口服脂肪耐量试验（OFTT）后的餐后血脂情况。
对21名符合成人治疗小组III定义的患有代谢综合征的绝经后女性和12名健康绝经后女性进行口服脂肪耐量试验。在口服脂肪耐量试验前以及试验后2、4、6和8小时测量甘油三酯（TG）水平。餐后反应通过甘油三酯水平曲线下面积（AUC）进行量化。患有代谢综合征的女性根据体重指数（BMI）<或>或=30kg/m²以及空腹甘油三酯水平<或>或=150mg/dl进行细分。
与健康组相比，代谢综合征组对口服脂肪耐量试验的反应显著更高[曲线下面积（标准差），单位为mg/dl/h；2014（933）对732（197），p<0.001]。体重指数<或>或=30kg/m²的受试者空腹甘油三酯水平相似[157（60）mg/dl对158（67）mg/dl]，曲线下面积也相似[分别为1975（898）和2072（1044）]。空腹甘油三酯水平>或=150mg/dl的代谢综合征女性的曲线下面积高于空腹甘油三酯水平<150mg/dl的女性[2502（854）对1281（441），p=0.002]。在线性回归分析中，将体重指数、高密度脂蛋白胆固醇、空腹甘油三酯、胰岛素抵抗指数（HOMA-IR）和定量胰岛素敏感性检查指数（QUICKI）作为自变量，只有空腹甘油三酯能显著预测曲线下面积（系数B=11.866，p=0.008）。
空腹甘油三酯浓度是餐后血脂的主要决定因素。肥胖状态并非代谢综合征女性餐后反应过度的额外决定因素。异常的餐后血脂可作为代谢综合征的一种重要代谢紊乱补充进去。
