Yoshikata Remi, Miyahara Yuko, Onoe Yoshiko, Okano Hiroya, Ohta Hiroaki
Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan.
J Obstet Gynaecol Res. 2008 Dec;34(6):1032-6. doi: 10.1111/j.1447-0756.2008.00800.x.
To explore the clinical implications of postprandial hypertriglyceridemia in postmenopausal Japanese women.
Postprandial blood samples were collected from 91 women at their initial visit, with fasting blood samples collected within the following month to examine their lipid profiles. These women were grouped into normotriglyceridemia (fasting/postprandial triglycerides [TG] < 150; n = 36), mild postprandial hypertriglyceridemia (fasting TG < 150, postprandial TG > or = 150, < 225; n = 27), moderate postprandial hypertriglyceridemia (fasting TG < 150, postprandial TG > or = 225; n = 19) and hypertriglyceridemia (fasting TG > or = 150; n = 9) by using 225 mg/dL as the cut-off value for postprandial hypertriglyceridemia.
The subjects were 54.1 +/- 7.8 years old; their duration of menopause, 6.0 +/- 7.7 years; body mass index, 21.4 +/- 4.0 kg/m(2); postprandial TG concentration, 189 +/- 110 mg/dL; and fasting TG concentration, 109 +/- 50 mg/dL. Approximately 50% (n = 46) of the women had normal fasting TG (fasting TG < 150), but high postprandial TG (postprandial TG > or = 150). Approximately 10% (n = 9) of the women had hypertriglyceridemia (fasting TG > or = 150 mg/dL). In those with postprandial hypertriglyceridemia (n = 46), postprandial TG negatively correlated with high-density lipoprotein cholesterol (HDL-C), while fasting TG showed no such correlation with HDL-C.
Postprandial TG may provide a better understanding of lipid metabolism in postmenopausal women.
探讨绝经后日本女性餐后高甘油三酯血症的临床意义。
对91名女性首次就诊时采集餐后血样，并在接下来的一个月内采集空腹血样以检测血脂谱。根据餐后高甘油三酯血症的临界值225mg/dL，将这些女性分为正常甘油三酯血症组（空腹/餐后甘油三酯[TG]<150；n = 36）、轻度餐后高甘油三酯血症组（空腹TG<150，餐后TG≥150，<225；n = 27）、中度餐后高甘油三酯血症组（空腹TG<150，餐后TG≥225；n = 19）和高甘油三酯血症组（空腹TG≥150；n = 9）。
受试者年龄为54.1±7.8岁；绝经时间为6.0±7.7年；体重指数为21.4±4.0kg/m²；餐后TG浓度为189±110mg/dL；空腹TG浓度为109±50mg/dL。约50%（n = 46）的女性空腹TG正常（空腹TG<150），但餐后TG高（餐后TG≥150）。约10%（n = 9）的女性患有高甘油三酯血症（空腹TG≥150mg/dL）。在餐后高甘油三酯血症患者（n = 46）中，餐后TG与高密度脂蛋白胆固醇（HDL-C）呈负相关，而空腹TG与HDL-C无此相关性。
餐后TG可能有助于更好地了解绝经后女性的脂质代谢。
