Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK.
Metabolism. 2013 Aug;62(8):1065-9. doi: 10.1016/j.metabol.2013.03.001. Epub 2013 Apr 15.
Studies have started to question whether a specific component or combinations of metabolic syndrome (MetS) components may be more important in relation to cardiovascular disease risk. Our aim was to examine the impact of the presence of raised fasting glucose as a MetS component on postprandial lipaemia.
Men classified with the MetS underwent a sequential test meal investigation, in which blood samples were taken at regular intervals after a test breakfast (t=0 min) and lunch (t=330 min). Lipids, glucose and insulin were measured in the fasting and postprandial samples.
MetS subjects with 3 or 4 components were subdivided into those without (n=34) and with (n=23) fasting hyperglycaemia (≥5.6 mmol/l), irrespective of the combination of components. Fasting lipids and insulin were similar in the two groups, with glucose significantly higher in the men with glucose as a MetS component (P<0.001). Following the test meals, there were higher maximum concentration (maxC), area under the curve (AUC) and incremental AUC (P ≤0.016) for the postprandial triacylglycerol (TAG) response in men with fasting hyperglycaemia. Greater glucose AUC (P<0.001) and insulin maxC (P=0.010) were also observed in these individuals after the test meals. Multiple regression analysis revealed fasting glucose to be an important predictor of the postprandial TAG and glucose response.
Our data analysis has revealed a greater impairment of postprandial TAG than glucose response in MetS subjects with raised fasting glucose. The worsening of postprandial lipaemic control may contribute to the greater CVD risk reported in individuals with MetS component combinations which include hyperglycaemia.
研究开始质疑代谢综合征（MetS）特定成分或成分组合是否与心血管疾病风险更为相关。我们的目的是检查作为 MetS 成分的空腹血糖升高对餐后脂血症的影响。
患有 MetS 的男性接受了连续测试餐研究，在测试早餐（t=0 分钟）和午餐（t=330 分钟）后定期采集血液样本。空腹和餐后样本中测量了脂质、葡萄糖和胰岛素。
将具有 3 或 4 个成分的 MetS 受试者分为无（n=34）和有（n=23）空腹高血糖（≥5.6mmol/l），无论成分组合如何。两组空腹血脂和胰岛素相似，血糖在 MetS 成分中血糖升高的男性中显著升高（P<0.001）。在测试餐后，空腹高血糖男性的餐后三酰甘油（TAG）反应的最大浓度（maxC）、曲线下面积（AUC）和增量 AUC 更高（P ≤0.016）。在这些个体中，餐后葡萄糖 AUC（P<0.001）和胰岛素 maxC（P=0.010）也更高。多元回归分析显示，空腹血糖是餐后 TAG 和葡萄糖反应的重要预测因素。
我们的数据分析显示，空腹血糖升高的 MetS 受试者的餐后 TAG 反应比葡萄糖反应受损更严重。餐后脂血症控制恶化可能导致报告的包括高血糖在内的 MetS 成分组合个体的 CVD 风险增加。
