Rodgers J K, Sawhney R, Chaudhary U, Bissada N K
Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC 72202-3591, USA.
Arch Androl. 2006 Mar-Apr;52(2):129-33. doi: 10.1080/01485010500315925.
Radical prostatectomy and radiotherapy are the most commonly utilized modalities for managing patients with localized prostate cancer. Each has effects on quality of life that are important in decision making. Long term side effects of these treatment modalities include urinary, bowel and sexual dysfunction, and have been documented. Comparison of the side effects of these different modalities continues to be explored, emphasizing their effects on quality of life (QOL) from the patient's viewpoint. Questionnaires were mailed to 224 eligible patients and a response was elicited in 161 men (72%). The final number of patients who completed all the questionnaires was 151. Of these, 73 (48%) had radical prostatectomy and 78 (52%) had radiotherapy. General well being measures demonstrated a definite advantage favoring men treated with radical prostatectomy. Prostate cancer specific QOL measures were similar among men treated with surgery or radiotherapy. Radiotherapy treated men were slightly more likely to report bowel-related problems than surgically treated men. Urinary QOL measures were no different between treated groups. Surgically treated men reported lower level of sexual function than radiotherapy treated men.
根治性前列腺切除术和放射治疗是治疗局限性前列腺癌患者最常用的方法。每种方法对生活质量都有影响，这在决策过程中很重要。这些治疗方法的长期副作用包括泌尿、肠道和性功能障碍，并且已有相关记录。人们一直在探索比较这些不同方法的副作用，从患者的角度强调它们对生活质量（QOL）的影响。向224名符合条件的患者邮寄了问卷，161名男性（72%）给出了回复。完成所有问卷的患者最终人数为151人。其中，73人（48%）接受了根治性前列腺切除术，78人（52%）接受了放射治疗。总体健康状况测量结果显示，接受根治性前列腺切除术治疗的男性具有明显优势。接受手术或放射治疗的男性中，前列腺癌特异性生活质量测量结果相似。接受放射治疗的男性比接受手术治疗的男性更有可能报告与肠道相关的问题。治疗组之间的泌尿生活质量测量结果没有差异。接受手术治疗的男性报告的性功能水平低于接受放射治疗的男性。
