Mayanagi M, Nakayama S, Oguchi K
Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan.
Nihon Yakurigaku Zasshi. 1992 Jul;100(1):29-37. doi: 10.1254/fpj.100.29.
The effects of hot water extracts (HWEs) from 15 kinds of Compositae herbs and distanninized fractions (DTFs) from 9 of these herbs on rat hepatic lipid peroxidation (LPO) and the activities of aminopyrine N-demethylase (APD) and aniline hydroxylase (ANH) were examined in vitro. The APD activity was inhibited by HWEs from 12 herbs, of which the effect of HWE from Inchinko was remarkable. Inhibitory effects of DTFs from Inchinko, Gaiyo, Kantoka, Sojustu and Byakujutsu on the APD activity were smaller, if any, than those of the corresponding HWEs, whereas DTF from Koka enhanced the activity of APD. The ANH activity was inhibited by HWEs from 11 herbs. HWEs from Inchinko, Gaiyo and Senpukuka increased the ANH activity, whereas the DTFs from them caused inhibition. The inhibitory effect of DTF from Shion on the ANH activity was smaller than that of the corresponding HWE, but the effects of DTFs from Koka, Byakujutsu, Sojutsu and Mokko were larger than those of the respective HWEs. LPO was inhibited by HWEs from 14 herbs, of which the HWEs from Inchinko, Gaiyo, Kantoka, Koka and Mokko caused marked inhibitions. Except in the case of Shion, the inhibitory effects of DTFs on LPO were smaller than those of the corresponding HWEs, whereas DTF from Koka still showed a marked inhibition. In the present experiments, it is suggested that Inchinko, Gaiyo, Koka, Kikuka, Senpukuka, Byakujutsu, Sojutsu and Mokko, which showed remarkable effects on LPO and the activities of APD and ANH, might also exert their effects in vivo.
研究了15种菊科草药的热水提取物（HWEs）以及其中9种草药的二锡化馏分（DTFs）对大鼠肝脏脂质过氧化（LPO）以及氨基比林N-脱甲基酶（APD）和苯胺羟化酶（ANH）活性的体外影响。12种草药的HWEs抑制了APD活性，其中茵陈蒿的HWEs作用显著。茵陈蒿、款冬、甘菊、苍术和白术的DTFs对APD活性的抑制作用（若有）比相应的HWEs小，而高良姜的DTF增强了APD活性。11种草药的HWEs抑制了ANH活性。茵陈蒿、款冬和旋覆花的HWEs增加了ANH活性，而它们的DTFs则产生抑制作用。紫菀的DTF对ANH活性的抑制作用比相应的HWE小，但高良姜、白术、苍术和木香的DTFs的作用比各自的HWEs大。14种草药的HWEs抑制了LPO，其中茵陈蒿、款冬、甘菊、高良姜和木香的HWEs产生了显著抑制作用。除紫菀外，DTFs对LPO的抑制作用比相应的HWEs小，而高良姜的DTF仍表现出显著抑制作用。在本实验中，提示对LPO以及APD和ANH活性有显著影响的茵陈蒿、款冬、高良姜、菊苣、旋覆花、白术、苍术和木香在体内可能也发挥作用。
