Nakayama S, Koizumi K, Iijima K, Mayanagi M, Oguchi K
Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan.
Nihon Yakurigaku Zasshi. 1993 May;101(5):327-36. doi: 10.1254/fpj.101.5_327.
The effects of hot water extracts (HWEs) and distanninized fractions (DTFs) from 9 kinds of Labiatae herbs on rat hepatic lipid peroxidation (LPO) and the activities of aminopyrine N-demethylase (APD) and aniline hydroxylase (ANH) were examined in vitro. The APD activity was inhibited by the HWEs from 6 herbs, of which the effect of HWE from Ogon was remarkable. The APD activity was increased by HWE from Shisoshi. The inhibitory effect of the HWE from Ogon was not different compared that of the DTF from Ogon, whereas the APD activity was decreased in the DTF from Shisoshi in comparison with that of the HWE. The ANH activity was inhibited by the HWEs from 7 herbs. Except in the case of Kakko and Shisoyo, the inhibitory effects of the HWEs were enhanced by these of the DTFs from the 7 herbs, of which the effect of DTF from Ogon was remarkable. LPO was inhibited by the HWEs from 8 herbs. Especially, HWE from Ogon strikingly inhibited LPO, and this effect was retained by the DTF from Ogon. The present results suggested that Ogon, which showed remarkable effects on LPO, and the activities of APD and ANH might also exert their effects in vivo.
研究了9种唇形科草药的热水提取物（HWEs）和二锡化组分（DTFs）对大鼠肝脏脂质过氧化（LPO）以及氨基比林N-脱甲基酶（APD）和苯胺羟化酶（ANH）活性的体外影响。6种草药的HWEs抑制了APD活性，其中欧甘菊的HWEs作用显著。石蚕的HWEs使APD活性升高。欧甘菊的HWEs与欧甘菊的DTF相比，抑制作用无差异，而石蚕的DTF与HWE相比，APD活性降低。7种草药的HWEs抑制了ANH活性。除了藿香和紫苏外，7种草药的DTFs增强了HWEs的抑制作用，其中欧甘菊的DTF作用显著。8种草药的HWEs抑制了LPO。特别是，欧甘菊的HWEs显著抑制LPO，且这种作用在欧甘菊的DTF中得以保留。目前的结果表明，对LPO以及APD和ANH活性有显著作用的欧甘菊可能在体内也发挥其作用。
