Monzavi Roshanak, Cohen Pinchas
Mattel Children's Hospital, David Geffen School Of Medicine at UCLA, 10833 Le Conte Avenue, MDCC 22-315, Los Angeles, CA 90095-1752, USA.
Best Pract Res Clin Endocrinol Metab. 2002 Sep;16(3):433-47. doi: 10.1053/beem.2002.0212.
The insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP proteases are the main regulators of somatic growth and cellular proliferation. IGFs are involved in growth pre-natally and post-natally. Dysregulation of the IGF axis can lead to growth disorders such as growth hormone deficiency and acromegaly. Pre-natally, this dysregulation can lead to IUGR or macrosomia. IGFs also have an important mitogenic action and play a role in tumorigenesis and cancer. These actions are regulated by co-interactions with IGFBPs, especially IGFBP-3. In addition to somatic growth and mitogenic activity, IGFs have hypoglycaemic and insulin sensitizing actions, and their dysregulation is involved in diabetes and its complications. In this chapter, we examine the role of IGFs and IGFBPs in growth, tumorigenesis and diabetes, and discuss treatment modalities for each disease involving the GH-IGF-IGFBP axis, including discussion of current in vitro and in vivo investigations in this field.
胰岛素样生长因子（IGFs）、胰岛素样生长因子结合蛋白（IGFBPs）以及IGFBP蛋白酶是体细胞生长和细胞增殖的主要调节因子。IGFs在出生前和出生后均参与生长过程。IGF轴失调可导致生长障碍，如生长激素缺乏症和肢端肥大症。在出生前，这种失调可导致宫内生长受限（IUGR）或巨大儿。IGFs还具有重要的促有丝分裂作用，并在肿瘤发生和癌症中发挥作用。这些作用通过与IGFBPs（尤其是IGFBP-3）的协同相互作用来调节。除了体细胞生长和促有丝分裂活性外，IGFs还具有降血糖和胰岛素增敏作用，其失调与糖尿病及其并发症有关。在本章中，我们将探讨IGFs和IGFBPs在生长、肿瘤发生和糖尿病中的作用，并讨论涉及生长激素-IGF-IGFBP轴的每种疾病的治疗方式，包括对该领域当前体外和体内研究的讨论。
