de Godoy José Maria Pereira, de Godoy Moacir Fernandes, Braile Domingo Marcolino
Department of Cardiology and Vascular Surgery, São José do Rio Preto University School of Medicine, São Paulo, Brazil.
Angiology. 2006 Jan-Feb;57(1):79-83. doi: 10.1177/000331970605700111.
Anticardiolipin antibodies represent one of the main hypercoagulation states associated with venous thromboembolism. The aim of this work was to evaluate symptomatic recurrent thrombosis in patients with anticardiolipin antibodies and deep vein thrombosis of the lower limbs with or without thromboembolism. Sixty patients who suffered from deep vein thrombosis were observed for a 5-year period, whether they had anticardiolipin antibodies or not. The group was made up of 34 females and 26 males with ages ranging from 13 to 73 years. All were diagnosed with deep vein thrombosis by means of phlebography and were tested for anticardiolipin antibodies by use of the ELISA method. The symptomatic signs of recurrent thrombosis were evaluated during this period. In total, 56.6% of the group were considered above normal for anticardiolipin antibodies, 25% positive, another 31.6% borderline, and 43.4% negative. Patients were tested positive when the anticardiolipin antibody count was >15 units/mL, borderline between 10 and 15 units/mL, and normal when <10 units/mL. The method of relative risk was used for statistical analysis of the results. Four positive patients, 1 borderline, and 1 normal patient had recurrent events of thrombosis. In the statistical analysis the relative risk for recurrent thrombosis in the positive patients was 6.0; CI 95%; 1.2 to 29.5. In conclusion patients with deep vein thrombosis who are positive for anticardiolipin antibodies present a higher risk of recurrent thrombosis.
抗心磷脂抗体是与静脉血栓栓塞相关的主要高凝状态之一。这项研究的目的是评估患有抗心磷脂抗体且伴有或不伴有血栓栓塞的下肢深静脉血栓形成患者的症状性复发性血栓形成情况。对60例患有深静脉血栓形成的患者进行了为期5年的观察，无论他们是否有抗心磷脂抗体。该组由34名女性和26名男性组成，年龄在13岁至73岁之间。所有患者均通过静脉造影诊断为深静脉血栓形成，并采用ELISA法检测抗心磷脂抗体。在此期间评估复发性血栓形成的症状体征。总体而言，该组中56.6%的患者抗心磷脂抗体高于正常水平，25%呈阳性，另有31.6%处于临界值，43.4%为阴性。当抗心磷脂抗体计数>15单位/毫升时患者检测为阳性，10至15单位/毫升之间为临界值，<10单位/毫升时为正常。采用相对风险方法对结果进行统计分析。4例阳性患者、1例临界值患者和1例正常患者出现了复发性血栓形成事件。在统计分析中，阳性患者复发性血栓形成的相对风险为6.0；95%置信区间为1.2至29.5。总之，抗心磷脂抗体阳性的深静脉血栓形成患者出现复发性血栓形成的风险更高。
