Dalal Shalini, Zhukovsky Donna S
Department of Palliative Care and Rehabilitation Medicine, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
J Support Oncol. 2006 Jan;4(1):9-16.
The febrile response is a complex physiologic reaction to disease involving a cytokine-mediated rise in body temperature, generation of acute-phase reactants, and activation of numerous endocrinologic and immunologic systems. Understanding the basic mechanisms underlying this phenomenon helps to formulate rational approaches to treatment and interventions. In this article, the authors review the basic pathophysiology of fever, its contributing etiologies, and management approaches based on current evidence.
发热反应是机体对疾病的一种复杂生理反应,涉及细胞因子介导的体温升高、急性期反应物的产生以及众多内分泌和免疫系统的激活。了解这一现象背后的基本机制有助于制定合理的治疗和干预方法。在本文中,作者基于现有证据综述了发热的基本病理生理学、其成因及管理方法。