Østergaard Jens, Prause Jan Ulrik, Heegaard Steffen
Eye Pathology Institute, University of Copenhagen, Copenhagen, Denmark.
Acta Ophthalmol Scand. 2006 Feb;84(1):130-6. doi: 10.1111/j.1600-0420.2005.00543.x.
To carry out a retrospective clinicopathological evaluation of caruncular lesions.
Data were collected from all surgically removed and histopathologically evaluated caruncular lesions registered by Danish pathology departments during the 25-year period 1978-2002.
A total of 574 caruncular lesions were identified. The number of caruncular lesions increased significantly during the 25-year period. This was due to an increase in the number of benign lesions, whereas the number of premalignant and malignant lesions remained constant. A total of 550 (96%) of the lesions were benign. Naevus (n = 248, 43%) and papilloma (n = 131, 23%) were the most common neoplasms. Premalignant lesions (n = 10, 1.7%) were dominated by primary acquired melanosis (PAM) with atypia and epithelial dysplasia. Malignant lesions constituted a total of 14 neoplasms (2.4%), with basal cell carcinoma (n = 4, 0.7%) and lymphoma (n = 4, 0.7%) being the most frequent. The preoperative clinical diagnosis was correct in 286 (50%) of cases.
Caruncular lesions are predominately benign but the lesions are rare and diverse, making clinical diagnosis difficult. Referral of excised lesions for pathological examination is recommended.
对泪阜病变进行回顾性临床病理评估。
收集丹麦病理科在1978年至2002年25年间登记的所有手术切除并经组织病理学评估的泪阜病变数据。
共识别出574例泪阜病变。在这25年期间，泪阜病变的数量显著增加。这是由于良性病变数量增加，而癌前病变和恶性病变数量保持不变。共有550例（96%）病变为良性。痣（n = 248，43%）和乳头状瘤（n = 131，23%）是最常见的肿瘤。癌前病变（n = 10，1.7%）以伴有异型性的原发性后天性黑素沉着症（PAM）和上皮发育异常为主。恶性病变共有14例肿瘤（2.4%），其中基底细胞癌（n = 4，0.7%）和淋巴瘤（n = 4，0.7%）最为常见。术前临床诊断在286例（50%）病例中正确。
泪阜病变以良性为主，但病变罕见且多样，导致临床诊断困难。建议将切除的病变送检病理检查。
