Asgari Maryam, Leiferman Kristin M, Piepkorn Michael, Kuechle Melanie K
Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195-6524, USA.
Int J Dermatol. 2006 Feb;45(2):131-4. doi: 10.1111/j.1365-4632.2006.02357.x.
A pre-term, 7-week-old male infant presented with a recurrent pustular eruption involving his face and scalp with associated peripheral blood eosinophilia. Skin biopsy revealed spongiosis with numerous dermal and epidermal eosinophils without predominant follicular involvement. Immunohistology showed deposition of eosinophil granule major basic protein and eosinophil derived neurotoxin in the dermis and epidermis. He responded to conservative management. We discuss the differential diagnosis of neonatal eosinophilic pustular eruptions and suggest the term 'neonatal eosinophilic pustulosis' to best describe our case.
一名7周大的早产男婴出现反复的脓疱疹，累及面部和头皮，并伴有外周血嗜酸性粒细胞增多。皮肤活检显示海绵形成，真皮和表皮有大量嗜酸性粒细胞，毛囊未受累为主。免疫组织学显示嗜酸性粒细胞颗粒主要碱性蛋白和嗜酸性粒细胞衍生神经毒素在真皮和表皮沉积。他对保守治疗有反应。我们讨论了新生儿嗜酸性脓疱疹的鉴别诊断，并建议用“新生儿嗜酸性脓疱病”来最好地描述我们的病例。
