Iandiev Ianors, Biedermann Bernd, Reichenbach Andreas, Wiedemann Peter, Bringmann Andreas
Paul Flechsig Institute of Brain Research, University of Leipzig Medical Faculty, Jahnallee 59, 04109 Leipzig, Germany.
Neurosci Lett. 2006 May 8;398(3):264-7. doi: 10.1016/j.neulet.2006.01.010. Epub 2006 Jan 30.
Aquaporins are involved in the maintenance of ionic and osmotic balance in the central nervous system and in the eye. Whereas the expression of aquaporin-9 immunoreactivity in the brain has been described for catecholaminergic neurons and glial cells, the expression of aquaporin-9 in the neural retina is unclear. We examined the distribution of aquaporin-1 and -9 immunoreactivities in retinas of the rat. Aquaporin-9 immunoreactivity was expressed exclusively by tyrosine hydroxylase (TH) positive amacrine cells, while aquaporin-1 immunoreactivity was expressed by photoreceptor cells and by TH negative amacrine cells. The staining pattern of aquaporin-9 did not change up to 4 weeks after pressure-induced transient retinal ischemia. It is concluded that catecholaminergic, putatively dopaminergic, amacrine cells of the retina express aquaporin-9.
水通道蛋白参与中枢神经系统和眼睛中离子及渗透平衡的维持。虽然已报道水通道蛋白9免疫反应性在脑中的表达存在于儿茶酚胺能神经元和神经胶质细胞中，但水通道蛋白9在神经视网膜中的表达尚不清楚。我们检测了大鼠视网膜中水通道蛋白1和9免疫反应性的分布。水通道蛋白9免疫反应性仅由酪氨酸羟化酶（TH）阳性无长突细胞表达，而水通道蛋白1免疫反应性由光感受器细胞和TH阴性无长突细胞表达。压力诱导的短暂性视网膜缺血后长达4周，水通道蛋白9的染色模式没有变化。得出的结论是，视网膜中儿茶酚胺能、推测为多巴胺能的无长突细胞表达水通道蛋白9。
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