Vu Hop, Ianosi-Irimie Monica, Danchuk Svitlana, Rabon Edd, Nogawa Toshihiko, Kamano Yoshiaki, Pettit G Robert, Wiese Thomas, Puschett Jules B
Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Exp Biol Med (Maywood). 2006 Feb;231(2):215-20. doi: 10.1177/153537020623100212.
The study of the pathogenesis of preeclampsia has been hampered by a relative dearth of animal models. We developed a rat model of preeclampsia in which the excretion of a circulating inhibitor of Na/K ATPase, marinobufagenin (MBG), is elevated. These animals develop hypertension, proteinuria, and intrauterine growth restriction. The administration of a congener of MBG, resibufogenin (RBG), reduces blood pressure to normal in these animals, as is the case when given to pregnant animals rendered hypertensive by the administration of MBG. Studies of Na/K ATPase inhibition by MBG and RBG reveal that these agents are equally effective as inhibitors of the enzyme.
先兆子痫发病机制的研究因动物模型相对匮乏而受阻。我们建立了一种先兆子痫大鼠模型，其中循环中的钠钾ATP酶抑制剂海蟾蜍精（MBG）的排泄量升高。这些动物会出现高血压、蛋白尿和子宫内生长受限。给予MBG的同类物脂蟾毒配基（RBG）可使这些动物的血压恢复正常，给予因注射MBG而患高血压的妊娠动物时也是如此。对MBG和RBG抑制钠钾ATP酶的研究表明，这些药物作为该酶的抑制剂同样有效。
