蟾毒配基给药可预防人子痫前期大鼠模型中的氧化应激。
Resibufogenin administration prevents oxidative stress in a rat model of human preeclampsia.
作者信息
Uddin Mohammad Nasir, Agunanne Enoch E, Horvat Darijana, Puschett Jules B
机构信息
Department of Medicine, Division of Nephrology and Hypertension, Texas A&M Health Science Center College of Medicine and Scott & White Memorial Hospital, Temple, TX, USA.
出版信息
Hypertens Pregnancy. 2012;31(1):70-8. doi: 10.3109/10641955.2010.525275. Epub 2010 Dec 21.
BACKGROUND AND OBJECTIVES
Marinobufagenin (MBG) is a cardiotonic steroid that is increased in preeclampsia. An analog of MBG, resibufogenin (RBG), prevents the development of preeclampsia in a rat model. Oxidative stress is a concomitant of endothelial dysfunction in the latter disorder. The objective of the current studies was to evaluate the status of oxidative stress in a rat model of preeclampsia.
METHODS
We measured the aortic AT(1) receptor expression and urinary excretion of 8-isoprostane (8IP) in rats rendered "preeclamptic" and compared the findings to those obtained in normal pregnant animals, pregnant rats injected with MBG, and preeclamptic rats treated with RBG.
RESULTS
Aortic AT(1) receptor expression and the urinary excretion of 8IP were significantly augmented in "preeclamptic" and MBG-injected pregnant rats compared to normal pregnant animals. RBG prevented evidence of oxidative stress in "preeclamptic" rats.
CONCLUSION
MBG is involved in the causation of oxidative stress in our rat model and RBG attenuates this change.
背景与目的
海蟾蜍精（MBG）是一种强心甾体，在先兆子痫患者体内含量升高。MBG的类似物脂蟾毒配基（RBG）可预防大鼠模型中先兆子痫的发生。氧化应激是后者疾病中内皮功能障碍的伴随症状。本研究的目的是评估先兆子痫大鼠模型中的氧化应激状态。
方法
我们测量了“先兆子痫”大鼠的主动脉AT(1)受体表达和尿中8-异前列腺素（8IP）的排泄量，并将结果与正常妊娠动物、注射MBG的妊娠大鼠以及用RBG治疗的先兆子痫大鼠的结果进行比较。
结果
与正常妊娠动物相比，“先兆子痫”和注射MBG的妊娠大鼠的主动脉AT(1)受体表达和尿中8IP的排泄量显著增加。RBG可预防“先兆子痫”大鼠出现氧化应激迹象。
结论
在我们的大鼠模型中，MBG参与了氧化应激的发生，而RBG可减轻这种变化。
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