Shimoyama Kumiko, Ogawa Noriyoshi, Sawada Jin, Kimoto Osamu, Suzuki Daisuke, Hayashi Hideharu
The Third Department of Internal Medicine, Hamamatsu University School of Medicine.
Nihon Rinsho Meneki Gakkai Kaishi. 2009 Feb;32(1):53-60. doi: 10.2177/jsci.32.53.
Minor salivary gland biopsy is useful for diagnosis of Sjögren's Syndrome, because it has 87.4% of sensitivity, 87.3% of specificity and 87.4% of accuracy. However, SS cannot be diagnosed solely on focus score (FS). Moreover, FS is at most semi-quantitative. We questioned 30 registered facilities of Society of Japan Sjögren's Syndrome about the method and evaluation of minor salivary gland biopsy. As a result, it turned out that there were no standard methods in the procedure of salivary gland biopsy. The small salivary gland can be reached easily with little invasive method, however there are several problems, which include 1. necessity of a standard technique, 2. minimization of the pain and 3. establishment of proper evaluation system. It is thought that the establishment of a standard technique and evaluation method is necessary to minimize the pain and collect the sufficient amount of tissue. Here we report the analysis of the procedure of minor salivary gland biopsy performed in other institutions as well as in our hospital in order to propose a standardized procedure and evaluation system.
小唾液腺活检对干燥综合征的诊断很有用，因为其敏感性为87.4%，特异性为87.3%，准确性为87.4%。然而，不能仅根据灶性评分（FS）来诊断干燥综合征。此外，FS最多只是半定量的。我们就小唾液腺活检的方法和评估向日本干燥综合征协会的30个注册机构进行了询问。结果发现，唾液腺活检过程中没有标准方法。小唾液腺可以通过微创方法轻松触及，但存在几个问题，包括1. 需要标准技术，2. 尽量减轻疼痛，3. 建立适当的评估系统。人们认为，建立标准技术和评估方法对于尽量减轻疼痛和获取足够的组织量是必要的。在此，我们报告对其他机构以及我们医院进行的小唾液腺活检过程的分析，以提出标准化的程序和评估系统。
