一名免疫功能低下患者的西尼罗河病毒持续性神经侵袭性感染。
Persistent neuroinvasive West Nile virus infection in an immunocompromised patient.
作者信息
Penn Robert G, Guarner Jeannette, Sejvar James J, Hartman Herbert, McComb Rodney D, Nevins Diana L, Bhatnagar Julu, Zaki Sherif R
机构信息
Department of Epidemiology, Methodist Hospital, Omaha, Nebraska, USA.
出版信息
Clin Infect Dis. 2006 Mar 1;42(5):680-3. doi: 10.1086/500216. Epub 2006 Jan 25.
A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were detected. This patient's case raises important issues related to the diagnosis, pathogenesis, and possible treatment of persistent WNV infection.
一名曾接受B细胞淋巴瘤治疗的57岁男性出现西尼罗河病毒（WNV）脑膜脑炎。在其99天的住院期间，未检测到WNV特异性抗体。在尸检时获取的死后中枢神经系统样本中，检测到了WNV RNA和WNV抗原。该患者的病例引发了与持续性WNV感染的诊断、发病机制及可能的治疗相关的重要问题。
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