Budimir Natali, Blais Jean-Claude, Fournier Françoise, Tabet Jean-Claude
Equipe de Spectrométrie de masse (LCSOB) UMR 7613 CNRS (Synthèse, Structure et Fonction de Molécules Bioactives), B45, Université Pierre et Marie Curie, 4 place Jussieu, 75252 Paris Cedex 05, France.
Rapid Commun Mass Spectrom. 2006;20(4):680-4. doi: 10.1002/rcm.2363.
The study of low molecular weight compounds by matrix-assisted laser desorption/ionization (MALDI) is difficult because of the presence of ions originating from the matrix in the low-m/z range. In order to resolve these problems, new matrix-free approaches were developed based on laser desorption/ionization from the surface of various materials such as graphite and porous silicon. Our work involves the use of 'desorption ionization on porous silicon mass spectrometry' (DIOS-MS) in the negative ion mode to study fatty acid compounds. The potential of the DIOS-MS technique is shown and an insight into the ionization mechanism provided.
通过基质辅助激光解吸/电离（MALDI）对低分子量化合物进行研究存在困难，这是因为在低质荷比范围内存在源自基质的离子。为了解决这些问题，基于从石墨和多孔硅等各种材料表面进行激光解吸/电离开发了新的无基质方法。我们的工作涉及在负离子模式下使用“多孔硅质谱解吸电离”（DIOS-MS）来研究脂肪酸化合物。展示了DIOS-MS技术的潜力，并对电离机制进行了深入探讨。
