Wyatt Christina M, Winston Jonathan
Division of Nephrology, Box 1243, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
Curr Infect Dis Rep. 2006 Jan;8(1):76-81. doi: 10.1007/s11908-006-0038-0.
As survival continues to improve in the era of highly active antiretroviral therapy, kidney, liver, and cardiac disease have become increasingly important sources of mortality and morbidity in patients with HIV. The incidence of end-stage renal disease in patients with HIV is projected to increase, and the incidence of earlier chronic kidney disease, acute renal failure, and electrolyte abnormalities is likely to be much higher than appreciated. Both acute and chronic kidney disease are more common in the setting of advanced HIV, hepatitis coinfection or liver disease, and medication toxicity. Close collaboration between nephrologists and infectious disease specialists is important to facilitate the identification, diagnosis, and management of acute and chronic kidney disease in patients with HIV. Recently published guidelines highlight the increased awareness of kidney disease in the infectious disease community and provide guidelines for the detection and management of chronic kidney disease in patients with HIV.
在高效抗逆转录病毒治疗时代，随着患者生存率不断提高，肾脏、肝脏和心脏疾病已日益成为艾滋病毒感染者死亡和发病的重要原因。预计艾滋病毒感染者终末期肾病的发病率将会上升，而早期慢性肾病、急性肾衰竭和电解质异常的发病率可能比目前所认识到的要高得多。急性和慢性肾病在晚期艾滋病毒感染、合并肝炎或肝脏疾病以及药物毒性情况下更为常见。肾病科医生和传染病专家之间密切合作对于促进艾滋病毒感染者急性和慢性肾病的识别、诊断及管理至关重要。最近发布的指南强调了传染病领域对肾病认识的提高，并为艾滋病毒感染者慢性肾病的检测和管理提供了指导方针。
