Diehl-Schmid J, Grimmer T, Drzezga A, Bornschein S, Riemenschneider M, Förstl H, Schwaiger M, Kurz A
Department of Psychiatry and Psychotherapy, Technische Universitaet Muenchen, Moehlstrasse 26, D-81675 Munich, Germany.
Neurobiol Aging. 2007 Jan;28(1):42-50. doi: 10.1016/j.neurobiolaging.2005.11.002. Epub 2006 Jan 31.
To identify the pattern of progression of decline of cerebral glucose metabolism in frontotemporal dementia (FTD, frontal variant).
22 patients with mild FTD underwent 18F-FDG-positron emission tomography at baseline and at follow-up in average 19.5 months later. Patient scans were compared with scans from 15 healthy age-matched control subjects on a voxel-by-voxel basis using SPM-99.
As compared with healthy control subjects at baseline patients with FTD showed a significant symmetrical hypometabolism of the frontal lobes sparing the motor cortex, of the caudate nuclei, insula and thalamus bilaterally. At follow-up further significant reductions in glucose metabolism were observed in the parietal and temporal cortices.
In early stages of FTD the neurodegenerative process is limited to the frontal lobes. During the progression of the disease, the pathological changes pass over the lobar borders and spread into the parietal and temporal cortices.
确定额颞叶痴呆（FTD，额叶变异型）患者脑葡萄糖代谢下降的进展模式。
22例轻度FTD患者在基线期及平均19.5个月后的随访期接受了18F - FDG正电子发射断层扫描。使用SPM - 99，将患者的扫描图像与15名年龄匹配的健康对照受试者的扫描图像逐体素进行比较。
与基线期的健康对照受试者相比，FTD患者双侧额叶、尾状核、岛叶和丘脑存在明显的对称性代谢减低，运动皮质未受累。随访时，顶叶和颞叶皮质葡萄糖代谢进一步显著降低。
在FTD早期，神经退行性变过程局限于额叶。在疾病进展过程中，病理改变跨越脑叶边界，扩散至顶叶和颞叶皮质。
