Cordes Nils
OncoRay-Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden,Fetscherstrasse 74/PF 86, 01307 Dresden, Germany.
Cancer Lett. 2006 Oct 8;242(1):11-9. doi: 10.1016/j.canlet.2005.12.004. Epub 2006 Jan 31.
Interactions of cells with their microenvironment modify the cellular sensitivity of normal and tumor cells for radiation- and drug-induced genotoxic injury. The preexistent or acquired cellular resistance against such agents aggravates anticancer therapies and, therefore, complicates the recovery of patients. Recently, integrin-mediated adhesion was shown to improve cell survival of both normal and cancer cells following DNA damage. Here, I will discuss the role of integrins and integrin-mediated signaling cascades in the survival or death response upon genotoxic stress. Detailed knowledge of the responsible molecular processes might provide implications for putative therapies targeting integrins or integrin-associated molecules to achieve an optimization of anticancer treatments.
细胞与其微环境的相互作用会改变正常细胞和肿瘤细胞对辐射及药物诱导的基因毒性损伤的细胞敏感性。细胞对这些因素预先存在的或后天获得的抗性会加剧抗癌治疗的难度，从而使患者的康复变得复杂。最近研究表明，整合素介导的黏附作用可提高正常细胞和癌细胞在DNA损伤后的存活率。在此，我将讨论整合素以及整合素介导的信号级联反应在基因毒性应激下细胞存活或死亡反应中的作用。对相关分子过程的详细了解可能为针对整合素或整合素相关分子的潜在治疗方法提供启示，以实现抗癌治疗的优化。
