Grzesiak John J, Ho Jason C, Moossa Abdool R, Bouvet Michael
Department of Surgery, University of California, San Diego, CA, USA.
Pancreas. 2007 Nov;35(4):293-301. doi: 10.1097/mpa.0b013e31811f4526.
Pancreatic cancer is the fifth leading cause of adult cancer death in the United States, with 5-year survival rates of only 1% to 4%. Current therapeutic strategies generally result in only a few months of extended life. Recent evidence from several independent laboratories in vitro and in vivo indicate that integrin-mediated cell attachment to the extracellular matrix (ECM), components of which are highly up-regulated in pancreatic cancer, evokes phenotypes and signaling pathways that regulate tumor cell growth and migration. In this review, we will discuss our current understanding of the role of the ECM in directing pancreatic cancer growth, progression, and metastasis. Topics covered include a survey of the existing literature regarding the in vivo and in vitro expression of the ECM and its cell surface receptors, the integrins, in pancreatic cancer; mechanisms involved in the integrin-ECM-mediated malignant phenotype; and future directions for the study of the integrin-ECM axis and its role in pancreatic cancer progression, including potential therapeutic strategies.
胰腺癌是美国成年人癌症死亡的第五大主要原因，5年生存率仅为1%至4%。目前的治疗策略通常只能延长几个月的生命。来自几个独立实验室的最新体外和体内证据表明，整合素介导的细胞与细胞外基质（ECM）的附着，其成分在胰腺癌中高度上调，引发了调节肿瘤细胞生长和迁移的表型和信号通路。在这篇综述中，我们将讨论我们目前对细胞外基质在指导胰腺癌生长、进展和转移中作用的理解。涵盖的主题包括对现有文献的调查，这些文献涉及细胞外基质及其细胞表面受体整合素在胰腺癌中的体内和体外表达；整合素-细胞外基质介导的恶性表型所涉及的机制；以及整合素-细胞外基质轴及其在胰腺癌进展中的作用研究的未来方向，包括潜在的治疗策略。
