Bonan Paulo Rogério Ferreti, Kaminagakura Estela, Pires Fábio Ramoa, Vargas Pablo Agustin, Almeida Oslei Paes de
School of Dentistry, State University of Montes Claros, Minas Gerais, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Feb;101(2):205-11. doi: 10.1016/j.tripleo.2005.03.033. Epub 2005 Sep 19.
The aim of this work was to study cytokeratin (Ck) expression in initial radiation-induced oral mucositis.
Eleven cases of initial radiomucositis of the buccal mucosa and 9 normal specimens were immunostained for Ck 1, 5, 6, 7, 8, 10, 14, 16, 18, and 19 by immunoperoxidase method.
Expression of Ck 1, 6, 10, and 16 was stronger in mucositis than in normal mucosa. Ck 7, 8, and 18 were negative for both control and study groups. Ck 5, 13, and 14 were positive for both groups, nevertheless suprabasal staining for Ck 14 was more evident in mucositis than in the control group. Sporadic staining for Ck 19 was observed in 1 case of mucositis and in 2 controls.
Increased Ck expression can be associated with the reactive proliferation of the epithelium and increasing resistance of the oral mucosa during the initial phases of radiotherapy.
本研究旨在探讨细胞角蛋白（Ck）在放疗所致早期口腔黏膜炎中的表达情况。
采用免疫过氧化物酶法，对11例颊黏膜早期放射性黏膜炎患者及9例正常对照标本进行Ck 1、5、6、7、8、10、14、16、18和19免疫染色。
Ck 1、6、10和16在黏膜炎中的表达强于正常黏膜。Ck 7、8和18在对照组和研究组中均为阴性。Ck 5、13和14在两组中均为阳性，但Ck 14在黏膜炎中的基底上层染色比对照组更明显。在1例黏膜炎患者和2例对照中观察到Ck 19的散在染色。
放疗初期Ck表达增加可能与上皮的反应性增殖及口腔黏膜抵抗力增强有关。
