Jones Hendrée E, Suess Patricia, Jasinski Donald R, Johnson Rolley E
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Am J Addict. 2006 Jan-Feb;15(1):61-70. doi: 10.1080/10550490500419094.
A transition from methadone to buprenorphine without intervening withdrawal symptoms is critical for advancing the treatment of opioid-dependent patients. Four pregnant inpatients were transferred from methadone (65-85 mg) to five days of immediate release morphine (IRM) and then to buprenorphine (12-28 mg). Withdrawal scores decreased during the five days of IRM and subsequently increased over the first three days on buprenorphine. The transitional use of IRM appears safe for both mother and fetus. Withdrawal symptoms appeared during buprenorphine induction; however, these data suggest that the intensity of withdrawal symptoms may be lessened by the dose and frequency of buprenorphine administration.
在不引发戒断症状的情况下从美沙酮过渡到丁丙诺啡，对于推进阿片类药物依赖患者的治疗至关重要。四名住院孕妇从美沙酮（65 - 85毫克）转换为服用五天即释吗啡（IRM），然后再转换为丁丙诺啡（12 - 28毫克）。在服用IRM的五天内戒断评分下降，随后在服用丁丙诺啡的头三天又有所上升。IRM的过渡性使用对母亲和胎儿似乎都是安全的。在丁丙诺啡诱导期间出现了戒断症状；然而，这些数据表明，丁丙诺啡给药的剂量和频率可能会减轻戒断症状的强度。
