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妊娠期阿片类药物依赖的评估与管理。

Evaluation and management of opioid dependence in pregnancy.

机构信息

Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA.

出版信息

Psychosomatics. 2012 Sep-Oct;53(5):424-32. doi: 10.1016/j.psym.2012.04.003. Epub 2012 Aug 14.

DOI:10.1016/j.psym.2012.04.003
PMID:22902085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5298932/
Abstract

BACKGROUND

Opioid use disorders are a growing public health problem in the United States. Most women who are opioid-dependent are of childbearing age, and management of opioid dependence during pregnancy poses unique challenges. Assessment includes evaluation for addiction, withdrawal syndromes, and comorbid psychiatric diagnoses. Consultation-liaison (C-L) psychiatrists may also be involved in acute pain management, perinatal medication management, buprenorphine induction, and stabilization. For the past four decades, the standard of care has included methadone maintenance, but the increasing use of buprenorphine creates new treatment issues and opportunities.

OBJECTIVE

To educate C-L psychiatrists in emergency and obstetrical settings about the appropriate approach toward the evaluation and basic management of women with opioid dependence in pregnancy.

METHOD

The authors reviewed the consensus literature and all new treatment options on opioid dependence during pregnancy.

DISCUSSION

In this review, the authors summarize known and emerging management strategies for opioid dependence in pregnancy pertinent to C-L psychiatrists.

摘要

背景

在美国,阿片类药物使用障碍是一个日益严重的公共卫生问题。大多数阿片类药物依赖的女性都处于生育年龄,怀孕期间管理阿片类药物依赖带来了独特的挑战。评估包括成瘾、戒断综合征和合并精神科诊断的评估。联络精神病学家也可能参与急性疼痛管理、围产期药物管理、丁丙诺啡诱导和稳定。在过去的四十年中,标准的治疗方法包括美沙酮维持治疗,但丁丙诺啡的使用越来越多,这带来了新的治疗问题和机会。

目的

教育急诊和产科环境中的联络精神病学家,了解如何对妊娠期间阿片类药物依赖的女性进行评估和基本管理。

方法

作者回顾了关于妊娠期间阿片类药物依赖的共识文献和所有新的治疗选择。

讨论

在这篇综述中,作者总结了与联络精神病学家有关的妊娠期间阿片类药物依赖的已知和新兴管理策略。

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本文引用的文献

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Buprenorphine versus methadone in pregnant opioid-dependent women: a prospective multicenter study.美沙酮与丁丙诺啡用于妊娠阿片类药物依赖妇女:一项前瞻性多中心研究。
Eur J Clin Pharmacol. 2011 Oct;67(10):1053-9. doi: 10.1007/s00228-011-1049-9. Epub 2011 May 3.
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Substance use in pregnancy.孕期物质使用。
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Drugs and medicines in pregnancy: the placental disposition of opioids.妊娠期用药:阿片类药物在胎盘的处置。
Curr Pharm Biotechnol. 2011 May;12(5):797-803. doi: 10.2174/138920111795470859.
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Prenatal exposure to methadone and buprenorphine: a review of the potential effects on cognitive development.产前暴露于美沙酮和丁丙诺啡:对认知发育潜在影响的综述。
Child Neuropsychol. 2011;17(5):495-519. doi: 10.1080/09297049.2011.553591. Epub 2011 Jun 24.
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Maternal treatment with opioid analgesics and risk for birth defects.母亲使用阿片类镇痛药与出生缺陷风险。
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Methadone and perinatal outcomes: a retrospective cohort study.美沙酮与围生期结局:一项回顾性队列研究。
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Neonatal abstinence syndrome after methadone or buprenorphine exposure.美沙酮或丁丙诺啡暴露后的新生儿戒断综合征。
N Engl J Med. 2010 Dec 9;363(24):2320-31. doi: 10.1056/NEJMoa1005359.
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Fetal neurobehavioral effects of exposure to methadone or buprenorphine.胎儿暴露于美沙酮或丁丙诺啡的神经行为影响。
Neurotoxicol Teratol. 2011 Mar-Apr;33(2):240-3. doi: 10.1016/j.ntt.2010.09.003. Epub 2010 Sep 22.
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Intrapartum and postpartum analgesia for women maintained on buprenorphine during pregnancy.孕期使用丁丙诺啡产妇的分娩中和产后镇痛。
Eur J Pain. 2010 Oct;14(9):939-43. doi: 10.1016/j.ejpain.2010.03.002. Epub 2010 May 4.
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Gender issues in the pharmacotherapy of opioid-addicted women: buprenorphine.阿片类药物成瘾女性药物治疗中的性别问题:丁丙诺啡。
J Addict Dis. 2010 Apr;29(2):217-30. doi: 10.1080/10550881003684814.