Leibel Natasha I, Baumann Elizabeth E, Kocherginsky Masha, Rosenfield Robert L
University of Chicago Comer Children's Hospital, Section of Pediatric Endocrinology, 5841 South Maryland Avenue (M/C 5053), Chicago, IL 60637, USA.
J Clin Endocrinol Metab. 2006 Apr;91(4):1275-83. doi: 10.1210/jc.2005-1707. Epub 2006 Jan 31.
We determined the relationship of metabolic syndrome (MBS) to polycystic ovary syndrome (PCOS).
We tested the hypothesis that parental MBS is related to the PCOS phenotype in their offspring.
DESIGN/SETTING: We phenotyped for MBS and PCOS in our General Clinical Research Center.
Girls with PCOS, 12-19 yr old (n = 36, including one pair of siblings), and their parents (35 mothers, 19 fathers) were recruited from the Pediatric Endocrinology Clinic. Healthy girls, 12-19 yr old (n = 21), were recruited as a reference population.
We measured anthropometrics, blood pressure, fasting lipids and androgens, oral glucose tolerance, and ultrasonographically determined polycystic ovary status.
MBS in parents, and PCOS features in mothers, were related to the presence of PCOS features in probands.
Fathers had strikingly high prevalence of excess adiposity (94% were obese or overweight) and MBS (79%). Premenopausal mothers more commonly had MBS (36%) than features of PCOS (< or =22%). Polycystic ovaries in proband offspring of premenopausal mothers were associated with maternal polycystic ovaries only in a minority of cases. Proband polycystic ovary status was completely concordant to fathers' MBS status (P = 0.008), but not their own or their mothers' MBS status, in families whose premenopausal mothers lacked polycystic ovaries. Proband prevalence of MBS was 27.8%, 3-fold greater than expected for obesity status.
Familial factors related to paternal MBS seem to be fundamental to the pathogenesis of PCOS.
我们确定了代谢综合征（MBS）与多囊卵巢综合征（PCOS）之间的关系。
我们检验了这样一个假设，即父母的MBS与其后代的PCOS表型相关。
设计/地点：我们在综合临床研究中心对MBS和PCOS进行了表型分析。
从儿科内分泌诊所招募了12至19岁的PCOS女孩（n = 36，包括一对姐妹）及其父母（35名母亲，19名父亲）。招募了12至19岁的健康女孩（n = 21）作为对照人群。
我们测量了人体测量学指标、血压、空腹血脂和雄激素、口服葡萄糖耐量，并通过超声确定多囊卵巢状态。
父母的MBS以及母亲的PCOS特征与先证者的PCOS特征的存在情况相关。
父亲中肥胖率（94%为肥胖或超重）和MBS患病率（79%）极高。绝经前母亲患MBS（36%）的情况比患PCOS特征（≤22%）更为常见。绝经前母亲的先证者后代中的多囊卵巢仅在少数情况下与母亲的多囊卵巢相关。在绝经前母亲没有多囊卵巢的家庭中，先证者的多囊卵巢状态与父亲的MBS状态完全一致（P = 0.008），但与他们自己或母亲的MBS状态不一致。先证者的MBS患病率为27.8%，比肥胖状态预期的患病率高3倍。
与父亲MBS相关的家族因素似乎是PCOS发病机制的基础。
