Department of Obstetrics and Gynecology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey.
Division of Endocrinology, Metabolism, and Lipids, Emory University School of Medicine, Atlanta, Georgia.
Fertil Steril. 2018 Feb;109(2):356-364.e32. doi: 10.1016/j.fertnstert.2017.10.018. Epub 2018 Jan 11.
To provide an evidence-based assessment of metabolic syndrome, hypertension, and hyperlipidemia in first-degree relatives of women with polycystic ovary syndrome (PCOS).
Systematic review and meta-analysis.
Not applicable.
PATIENT(S): Mothers, fathers, sisters, and brothers of women with and without PCOS.
INTERVENTION(S): An electronic-based search with the use of PubMed from 1960 to June 2015 and cross-checked references of relevant articles.
MAIN OUTCOME MEASURE(S): Metabolic syndrome, hypertension and dyslipidemia, and surrogate markers, including systolic blood pressure (BP), diastolic BP, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides.
RESULT(S): Fourteen of 3,346 studies were included in the meta-analysis. Prevalence of the following was significantly increased in relatives of women with PCOS: metabolic syndrome (risk ratio [RR] 1.78 [95% confidence interval 1.37, 2.30] in mothers, 1.43 [1.12, 1.81] in fathers, and 1.50 [1.12, 2.00] in sisters), hypertension (RR 1.93 [1.58, 2.35] in fathers, 2.92 [1.92, 4.45] in sisters), and dyslipidemia (RR 3.86 [2.54, 5.85] in brothers and 1.29 [1.11, 1.50] in fathers). Moreover, systolic BP (mothers, sisters, and brothers), total cholesterol (mothers and sisters), low-density lipoprotein cholesterol (sisters), and triglycerides (mothers and sisters) were significantly higher in first-degree relatives of PCOS probands than in controls.
CONCLUSION(S): Our results show evidence of clustering for metabolic syndrome, hypertension, and dyslipidemia in mothers, fathers, sisters, and brothers of women with PCOS.
PROSPERO 2016 CRD42016048557.
对多囊卵巢综合征（PCOS）患者的一级亲属中的代谢综合征、高血压和高脂血症进行基于证据的评估。
系统评价和荟萃分析。
不适用。
有和没有 PCOS 的女性的母亲、父亲、姐妹和兄弟。
从 1960 年到 2015 年 6 月，使用基于电子的 PubMed 搜索，并交叉检查相关文章的参考文献。
代谢综合征、高血压和血脂异常以及替代标志物，包括收缩压（BP）、舒张压、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯。
在 3346 项研究中，有 14 项被纳入荟萃分析。患有 PCOS 的女性的亲属中，以下疾病的患病率显著增加：代谢综合征（母亲为 1.78 [95%置信区间 1.37，2.30]，父亲为 1.43 [1.12，1.81]，姐妹为 1.50 [1.12，2.00]）、高血压（父亲为 1.93 [1.58，2.35]，姐妹为 2.92 [1.92，4.45]）和血脂异常（兄弟为 3.86 [2.54，5.85]，父亲为 1.29 [1.11，1.50]）。此外，一级亲属的收缩压（母亲、姐妹和兄弟）、总胆固醇（母亲和姐妹）、低密度脂蛋白胆固醇（姐妹）和甘油三酯（母亲和姐妹）均显著高于对照组。
我们的研究结果表明，在患有 PCOS 的女性的母亲、父亲、姐妹和兄弟中，代谢综合征、高血压和血脂异常存在聚集现象。
PROSPERO 2016 CRD42016048557。
