Kawai K, Kawai K, Kamei N, Kishimoto S
Kawai Clinic, Kyoto Prefectural University of Medicine, Japan.
J Dermatol. 1992 May;19(5):285-92. doi: 10.1111/j.1346-8138.1992.tb03226.x.
Levels of serum IgE, serum soluble-Fc epsilon RII (S-Fc epsilon RII), and Fc epsilon RII(+) peripheral blood lymphocytes (PBL) were examined in 73 patients with atopic dermatitis (AD) and 17 control subjects with no atopic disease, in order to investigate the correlation of these parameters with AD. AD patients showed increases in IgE, S-Fc epsilon RII and Fc epsilon RII(+)PBL as compared with control subjects. In AD patients, levels of serum IgE and Fc epsilon RII(+)PBL increased as the extent of dermatitis became more severe, while levels of serum S-Fc epsilon RII showed no correlation with the extent of dermatitis. In 8 of the 73 AD patients who showed an improvement in their symptoms with treatment with topical corticosteroids or antihistamine, IgE, Fc epsilon RII(+)PBL, and S-Fc epsilon RII were measured before and after treatment. Fc epsilon RII(+)PBL correlated with disease activity; IgE and S-Fc epsilon RII did not show any such correlation. Patients with elevated IgE levels (IgE greater than 5,000 U/ml) showed low levels of S-Fc epsilon RII. Severely affected cases with a history of respiratory atopy also showed decreased S-Fc epsilon RII levels. It is believed that S-Fc epsilon RII binds to IgE in serum and may neutralize or down-regulate IgE mediated allergic reactions. A low level of S-Fc epsilon RII may cause an elevation of IgE and an exacerbation of the disease.
检测了73例特应性皮炎（AD）患者和17例无特应性疾病的对照者的血清IgE、血清可溶性FcεRII（S-FcεRII）水平以及FcεRII(+)外周血淋巴细胞（PBL），以研究这些参数与AD的相关性。与对照者相比，AD患者的IgE、S-FcεRII和FcεRII(+)PBL水平升高。在AD患者中，随着皮炎程度加重，血清IgE和FcεRII(+)PBL水平升高，而血清S-FcεRII水平与皮炎程度无相关性。在73例经外用糖皮质激素或抗组胺药治疗症状改善的AD患者中，8例在治疗前后检测了IgE、FcεRII(+)PBL和S-FcεRII。FcεRII(+)PBL与疾病活动相关；IgE和S-FcεRII未显示出此类相关性。IgE水平升高（IgE大于5000 U/ml）的患者S-FcεRII水平较低。有呼吸道特应性病史的重症患者S-FcεRII水平也降低。据信S-FcεRII与血清中的IgE结合，可能中和或下调IgE介导的过敏反应。S-FcεRII水平低可能导致IgE升高和疾病加重。
