Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Cells. 2023 Apr 12;12(8):1136. doi: 10.3390/cells12081136.
Integrin LFA-1 plays a critical role in T-cell migration and in the formation of immunological synapses. LFA-1 functions through interacting with its ligands with differing affinities: low, intermediate, and high. Most prior research has studied how LFA-1 in the high-affinity state regulates the trafficking and functions of T cells. LFA-1 is also presented in the intermediate-affinity state on T cells, however, the signaling to activate LFA-1 to the intermediate-affinity state and the role of LFA-1 in this affinity state both remain largely elusive. This review briefly summarizes the activation and roles of LFA-1 with varied ligand-binding affinities in the regulation of T-cell migration and immunological synapse formation.
整合素 LFA-1 在 T 细胞迁移和免疫突触形成中起着关键作用。LFA-1 通过与其配体以不同的亲和力相互作用来发挥作用：低、中、高。大多数先前的研究都研究了高亲和力状态下的 LFA-1 如何调节 T 细胞的运输和功能。然而，T 细胞上也存在中亲和力状态的 LFA-1，但是，激活 LFA-1 到中亲和力状态的信号以及 LFA-1 在这种亲和力状态下的作用在很大程度上仍不清楚。这篇综述简要总结了 LFA-1 在 T 细胞迁移和免疫突触形成中的不同配体结合亲和力的激活和作用。
