Matsui Hideaki, Udaka Fukashi, Tamura Akiko, Oda Masaya, Kubori Tamotsu, Nishinaka Kazuto, Kameyama Masakuni
Department of Neurology, Sumitomo Hospital, Osaka, Japan.
J Geriatr Psychiatry Neurol. 2006 Mar;19(1):36-40. doi: 10.1177/0891988705284739.
Pathophysiology of hallucinations in Parkinson's disease is poorly understood. This study investigated relationships between visual hallucinations and visual acuity. Twenty-six consecutive patients with Parkinson's disease participated in this study. Patients were divided into two groups: patients with visual hallucinations (VH group) and those without visual hallucinations (no-VH group). Unaided and corrected eyesight was evaluated in all patients, and if frequent use of prescription glasses or contact lenses was involved, eyesight using these lenses was also measured as the patient's own best eyesight. If a patient did not use prescription glasses or contact lenses, the patient's own best eyesight was defined as the unaided eyesight. Multivariate regression analysis demonstrated that agonist use and best eyesight were different after the backward elimination method. Visual hallucinations were closely related not to uncorrected eyesight or unaided eyesight but to the patient's best eyesight. It is suggested that impaired visual acuity is a risk factor for visual hallucinations.
帕金森病幻觉的病理生理学机制目前尚不清楚。本研究调查了视幻觉与视力之间的关系。26例连续的帕金森病患者参与了本研究。患者被分为两组：有视幻觉的患者（VH组）和无视幻觉的患者（无VH组）。对所有患者评估了裸眼视力和矫正视力，如果患者经常使用处方眼镜或隐形眼镜，则使用这些镜片时的视力也作为患者的最佳视力进行测量。如果患者不使用处方眼镜或隐形眼镜，则将患者的最佳视力定义为裸眼视力。多因素回归分析表明，采用向后剔除法后，激动剂的使用情况和最佳视力存在差异。视幻觉与未矫正视力或裸眼视力并无密切关系，而是与患者的最佳视力密切相关。提示视力受损是视幻觉的一个危险因素。
