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帕金森病精神病的全球研究趋势与热点:一项25年的文献计量学与可视化分析

Global research trends and hotspots in Parkinson's disease psychosis: a 25-year bibliometric and visual analysis.

作者信息

Wu Jianhong, Jin Xin, Xie Weiming, Liu Liang, Wang Fei, Zhu Ling, Shen Yuan, Qiu Linghe

机构信息

Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, Jiangsu, China.

Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China.

出版信息

Front Aging Neurosci. 2024 Nov 22;16:1480234. doi: 10.3389/fnagi.2024.1480234. eCollection 2024.

DOI:10.3389/fnagi.2024.1480234
PMID:39649718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11621064/
Abstract

BACKGROUND

Parkinson's disease psychosis (PDP) is one of the most severe and disabling non-motor symptoms in the progression of Parkinson's disease (PD), significantly impacting the prognosis of PD patients. In recent years, there has been an increase in literature on PDP. However, bibliometrics has rarely been applied to PDP research. This study provides an overview of the current state of PDP research and predicts future trends in this field.

METHODS

The literature search was conducted using the Web of Science Core Collection, with the search terms (Parkinson* AND (psychotic* OR hallucination* OR illusion* OR delusion* OR misperception* OR psychosis OR psychoses)). VOSviewer and CiteSpace software were employed to perform bibliometric analysis and visual representation of the search results.

RESULTS

A total of 603 articles were effectively included. Since 2017, there has been a significant upward trend in publications related to PDP. The United States, the United Kingdom, and Canada were the top three contributing countries in terms of publication volume, with France also having a strong influence in this field. and King's College London included and published the most articles on PDP. The paper titled "" received the highest number of citations and average citations. Cluster analysis results identified brain, prevalence, connectivity, and atypical antipsychotics as key hotspots in this field. High-frequency keywords were grouped into three themes: neurobiology, therapeutic strategies, and symptom research. Among them, pimavanserin, risk, and functional connectivity have been the most studied areas in the past 7 years and are likely to remain key topics in future research.

CONCLUSION

Research on PDP has garnered increasing attention. This study visualizes PDP research over the past 25 years to analyze global hotspots and trends. It offers researchers a valuable perspective for identifying key topics and understanding research trajectories in this expanding field.

摘要

背景

帕金森病精神病(PDP)是帕金森病(PD)进展过程中最严重且致残的非运动症状之一,对PD患者的预后有显著影响。近年来,关于PDP的文献不断增加。然而,文献计量学很少应用于PDP研究。本研究概述了PDP研究的现状,并预测了该领域的未来趋势。

方法

使用Web of Science核心合集进行文献检索,检索词为(Parkinson* AND (psychotic* OR hallucination* OR illusion* OR delusion* OR misperception* OR psychosis OR psychoses))。采用VOSviewer和CiteSpace软件对检索结果进行文献计量分析和可视化呈现。

结果

共有效纳入603篇文章。自2017年以来,与PDP相关的出版物数量呈显著上升趋势。美国、英国和加拿大是发表量排名前三的贡献国家,法国在该领域也有很大影响力。伦敦国王学院收录并发表的关于PDP的文章最多。题为《》的论文获得的引用次数和平均引用次数最高。聚类分析结果确定大脑、患病率、连通性和非典型抗精神病药物是该领域的关键热点。高频关键词被归为三个主题:神经生物学、治疗策略和症状研究。其中,匹莫范色林、风险和功能连通性是过去7年研究最多的领域,并且可能仍将是未来研究的关键主题。

结论

对PDP的研究越来越受到关注。本研究对过去25年的PDP研究进行可视化分析,以剖析全球热点和趋势。它为研究人员提供了一个有价值的视角,有助于识别该不断扩展领域中的关键主题并了解研究轨迹。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11621064/50cc7edbc08a/fnagi-16-1480234-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11621064/22eb5528797f/fnagi-16-1480234-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11621064/e17a7435b599/fnagi-16-1480234-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11621064/ee799beae81d/fnagi-16-1480234-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11621064/d0d1ce1ef0f8/fnagi-16-1480234-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11621064/50cc7edbc08a/fnagi-16-1480234-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11621064/22eb5528797f/fnagi-16-1480234-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11621064/e17a7435b599/fnagi-16-1480234-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11621064/ee799beae81d/fnagi-16-1480234-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11621064/d0d1ce1ef0f8/fnagi-16-1480234-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69ae/11621064/50cc7edbc08a/fnagi-16-1480234-g005.jpg

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Positive allosteric mGluR modulation with BINA alleviates dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset.BINA 通过正变构调节 mGluR,可减轻 MPTP 损毁恒河猴的运动障碍和精神病样行为。
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