Matsui Hideaki, Udaka Fukashi, Miyoshi Takafumi, Hara Narihiro, Tamura Akiko, Oda Masaya, Kubori Tamotsu, Nishinaka Kazuto, Kameyama Masakuni
Department of Neurology, Sumitomo Hospital, Osaka, Japan.
J Geriatr Psychiatry Neurol. 2006 Mar;19(1):41-5. doi: 10.1177/0891988705284714.
The objective was to compare brain perfusion image using 3-dimensional stereotactic surface projection analysis of N-isopropyl-p-123I iodoamphetamine single photon emission computed tomography between Parkinson's disease patients with a high frontal assessment battery score and those with a low frontal assessment battery score. Thirty nondemented patients with Parkinson's disease were studied. Patients were divided into 2 groups: a high-scoring group whose frontal assessment battery score was 12 or more and a low-scoring group whose frontal assessment battery score was 11 or less. The high-scoring group included 21 patients, and the low-scoring group included 9 patients. They underwent N-isopropyl-p-123I iodoamphetamine single photon emission computed tomography, and we analyzed the data by the 3-dimensional stereotactic surface projection method. Results showed that left inferior parietal lobule and left supramarginal gyrus perfusion of the low-scoring group were significantly decreased compared with the high-scoring group. It is concluded that patients with Parkinson's disease may have frontal lobe dysfunction, but the decreased frontal assessment battery score may be caused not by progressed frontal lobe dysfunction but by parietal lobe dysfunction added to their preexisting frontal lobe impairment.
目的是使用 N-异丙基-p-123I 碘安非他明单光子发射计算机断层扫描的三维立体定向表面投影分析，比较帕金森病患者中额叶评估量表得分高者与得分低者的脑灌注图像。研究了 30 名无痴呆的帕金森病患者。患者被分为两组：额叶评估量表得分 12 分及以上的高分组合得分 11 分及以下的低分组合。高分组包括 21 名患者，低分组合包括 9 名患者。他们接受了 N-异丙基-p-123I 碘安非他明单光子发射计算机断层扫描，我们通过三维立体定向表面投影法分析了数据。结果显示，与高分组合相比，低分组合的左侧顶下小叶和左侧缘上回灌注显著降低。结论是，帕金森病患者可能存在额叶功能障碍，但额叶评估量表得分降低可能不是由进展性额叶功能障碍引起的，而是由顶叶功能障碍叠加在其原有的额叶损害上所致。
