Kawabata K, Tachibana H, Sugita M
Fifth Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
J Geriatr Psychiatry Neurol. 1991 Oct-Dec;4(4):194-203. doi: 10.1177/089198879100400404.
Regional cerebral blood flow (CBF) was examined in 27 patients with Parkinson's disease using single-photon emission computed tomography and N-isopropyl-p-[123I]iodoamphetamine as a tracer. Their CBF pattern was compared with that of seven patients with Alzheimer's disease and nine age-matched neurologically normal controls. Tracer activity was determined in seven bilateral cerebellar, cortical, and subcortical regions and was expressed as the ratio of activity in each region to the mean tracer activity in the cerebellar region. Nineteen patients with nondemented Parkinson's disease showed significantly decreased tracer activity ratio in the frontal and temporal cortices, basal ganglia, and thalamus compared with that in controls. The eight demented Parkinson's disease patients showed significantly decreased tracer activity ratio in the temporal and parietal cortices compared with the patients without dementia, and demonstrated CBF pattern similar to that of patients with Alzheimer's disease. These findings suggest that in patients with Parkinson's disease, the mechanism of CBF reduction of the frontal cortical region differs from that in the temporoparietal cortical region and support the concept that Parkinson's disease and Alzheimer's disease may overlap in some patients.
使用单光子发射计算机断层扫描技术，并以N-异丙基-p-[123I]碘安非他明作为示踪剂，对27例帕金森病患者的局部脑血流量（CBF）进行了检测。将他们的CBF模式与7例阿尔茨海默病患者以及9例年龄匹配的神经功能正常对照者的CBF模式进行了比较。在七个双侧小脑、皮质和皮质下区域测定了示踪剂活性，并将其表示为每个区域的活性与小脑区域平均示踪剂活性的比值。与对照组相比，19例非痴呆型帕金森病患者在额叶和颞叶皮质、基底神经节和丘脑的示踪剂活性比值显著降低。与非痴呆患者相比，8例痴呆型帕金森病患者在颞叶和顶叶皮质的示踪剂活性比值显著降低，并且显示出与阿尔茨海默病患者相似的CBF模式。这些发现表明，在帕金森病患者中，额叶皮质区域CBF减少的机制与颞顶叶皮质区域不同，并支持帕金森病和阿尔茨海默病在某些患者中可能重叠的观点。
