Tachibana H, Kawabata K, Tomino Y, Sugita M, Fukuchi M
Fifth Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Neuroradiology. 1994 May;36(4):276-80. doi: 10.1007/BF00593259.
We reconstructed three-dimensional (3D) surface images from single-photon emission computed tomography (SPECT) data using N-isopropyl-p[123I]-iodoamphetamine (123I-IMP) in 27 patients with Parkinson's disease and 11 normal control subjects. The 3D reconstruction was performed using distance-shaded methods at threshold levels with an interval of 5% from 45-80%. Any area of decreased perfusion at each threshold level was visualised as a defect area by the algorithm. In nondemented patients with Parkinson's disease, perfusion defects were frequently found in the parietal cortex at a threshold value of 65%. In demented patients, perfusion defects were frequently seen at thresholds of 45-65%, and were more marked in the temporal and parietal cortex bilaterally. This suggests that dementia in Parkinson's disease is related to a reduction of perfusion in the temporoparietal cortex.
我们使用N-异丙基-p[123I]-碘安非他明（123I-IMP），从单光子发射计算机断层扫描（SPECT）数据中重建了27例帕金森病患者和11名正常对照者的三维（3D）表面图像。3D重建采用距离阴影法，在45%-80%的阈值水平上，以5%的间隔进行。算法将每个阈值水平下灌注减少的任何区域显示为缺损区域。在非痴呆的帕金森病患者中，在65%的阈值时，顶叶皮质经常发现灌注缺损。在痴呆患者中，在45%-65%的阈值时经常可见灌注缺损，并且在双侧颞叶和顶叶皮质中更为明显。这表明帕金森病中的痴呆与颞顶叶皮质灌注减少有关。
