Bajracharya B L, Baral M R, Shakya S, Tuladhar P, Paudel M, Acharya B
Department of Paediatrics, Kathmandu Medical College Teaching Hospital, Sinamangal, Kathmandu, Nepal.
Kathmandu Univ Med J (KUMJ). 2006 Jan-Mar;4(1):25-9.
The objective of this study is to evaluate the clinical profile and drug response in typhoid fever.
This is a retrospective analysis of paediatric patients suffering from typhoid fever who were admitted at Kathmandu Medical College Teaching Hospital, Sinamangal during the period of two years and nine months.
Total numbers of 100 cases of typhoid were studied. Diagnosis of Typhoid fever was based on clinical features, Widal test and blood culture. The sensitivity pattern of drugs in blood culture was recorded. The mode of presentation, treatment history, laboratory investigations reports, antibiotics administered and response to therapy were recorded.
Quinolone is still the highly sensitive drug and most widely used for Salmonella typhi. Because of the indiscriminate use of these drugs, resistant to ciprofloxacin has been quite high and the duration of the defeverscence period has also been prolonged. But Ofloxacin is still showed highly effective and widely used with good response.
本研究的目的是评估伤寒热的临床特征和药物反应。
这是一项对在两年零九个月期间入住加德满都医学院教学医院（位于辛纳芒加尔）的患伤寒热儿科患者的回顾性分析。
共研究了100例伤寒病例。伤寒热的诊断基于临床特征、肥达试验和血培养。记录了血培养中药物的敏感性模式。记录了临床表现方式、治疗史、实验室检查报告、使用的抗生素以及治疗反应。
喹诺酮类药物仍然是对伤寒杆菌高度敏感且使用最广泛的药物。由于这些药物的滥用，对环丙沙星的耐药性相当高，退热期也延长了。但氧氟沙星仍然显示出高效且广泛使用且反应良好。
