Mishra S, Patwari A K, Anand V K, Pillai P K, Aneja S, Chandra J, Sharma D
Department of Pediatrics, Lady Hardinge Medical College, New Delhi.
Indian Pediatr. 1991 Oct;28(10):1171-4.
Fifty blood culture positive patients of typhoid fever were studied during the current outbreak of the disease for their clinical profile. In 39 (78%) cases the isolates of S. typhi were resistant to conventional drugs. Children below 2 years of age constituted 20% of the total cases and belonged exclusively to the group with multidrug resistant typhoid fever (MRTF). The clinical presentation seemed to mimic malaria, bronchopneumonia, meningitis, etc. Typhoid hepatitis was diagnosed in 2 cases with MRTF. Life threatening complications were seen in 28.2% patients and were observed exclusively in MRTF group.
在本次伤寒疫情期间，对50例血培养阳性的伤寒患者进行了临床特征研究。在39例（78%）病例中，伤寒杆菌分离株对传统药物耐药。2岁以下儿童占总病例数的20%，且均属于多重耐药伤寒热（MRTF）组。临床表现似乎类似于疟疾、支气管肺炎、脑膜炎等。2例MRTF患者被诊断为伤寒性肝炎。28.2%的患者出现危及生命的并发症，且仅在MRTF组中观察到。
