Meltzer Eli O
Allergy and Asthma Medical Group and Research Center, 9610 Granite Ridge Drive, Suite B, San Diego, CA 92123, USA.
Allergy Asthma Proc. 2005 Sep-Oct;26(5):336-40.
Rhinitis and asthma are common airway conditions; however, recent data suggest that they both can be clinical manifestations of a systemic inflammatory process within the respiratory tract. The link between these two airway disorders has been called the "integrated airway hypothesis." Several epidemiological studies have established an association between rhinitis and asthma, and approximately 19-38% of patients with allergic rhinitis have coexistent asthma. Additionally, an understanding of the biology of the two airway disorders suggests that systemic inflammation after local allergen challenge links the upper and lower airways. More recently, data from clinical studies in patients with rhinitis and coexistent asthma have highlighted that an improved control of nasal symptoms frequently results in improved asthma symptom scores. To clarify the relationships between upper and lower airway disorders and to establish the potential benefits of an integrated airways management approach, additional studies are warranted.
鼻炎和哮喘是常见的气道疾病；然而，最近的数据表明，它们都可能是呼吸道内全身性炎症过程的临床表现。这两种气道疾病之间的联系被称为“气道整合假说”。多项流行病学研究已证实鼻炎与哮喘之间存在关联，约19% - 38%的过敏性鼻炎患者同时患有哮喘。此外，对这两种气道疾病生物学特性的认识表明，局部过敏原激发后的全身性炎症将上、下气道联系起来。最近，针对鼻炎合并哮喘患者的临床研究数据突出显示，改善鼻部症状的控制常常会使哮喘症状评分得到改善。为了阐明上、下气道疾病之间的关系并确定气道综合管理方法的潜在益处，有必要进行更多研究。
