Camiña J P
Laboratory of Molecular Endocrinology, Research Area, Complexo Hospitalario Universitario de Santiago (CHUS), PO Box 563, E-15780 Santiago de Compostela, Spain.
J Neuroendocrinol. 2006 Jan;18(1):65-76. doi: 10.1111/j.1365-2826.2005.01379.x.
Ghrelin, a gastric peptide involved in growth hormone release and energy homeostasis, is the endogenous ligand of the growth hormone secretagogue receptor type 1a (GHS-R1a), a G-protein coupled receptor mainly expressed in the pituitary and hypothalamus. This receptor mediates the main ghrelin-stimulated endocrine actions and some of the nonendocrine actions. However, a number of nonendocrine actions associated with ghrelin appear to be mediated by various GHS-R1a-related receptor subtypes, which are widely distributed in the central and peripheral tissues. This review summarises data concerning the localisation, regulation and function of GHS-R1a, as well as related receptors.
胃饥饿素是一种参与生长激素释放和能量平衡调节的胃肽，是生长激素促分泌素受体1a型（GHS-R1a）的内源性配体，GHS-R1a是一种主要在垂体和下丘脑表达的G蛋白偶联受体。该受体介导胃饥饿素刺激的主要内分泌作用以及一些非内分泌作用。然而，许多与胃饥饿素相关的非内分泌作用似乎是由各种与GHS-R1a相关的受体亚型介导的，这些受体亚型广泛分布于中枢和外周组织中。本文综述了有关GHS-R1a及其相关受体的定位、调节和功能的数据。
