Pontisso P, Ruvoletto M G, Tiribelli C, Gerlich W H, Ruol A, Alberti A
Istituto di Medicina Clinica, Clinica Medica 2, University of Padova, Italy.
J Gen Virol. 1992 Aug;73 ( Pt 8):2041-5. doi: 10.1099/0022-1317-73-8-2041.
Using a solid-phase assay we have demonstrated specific competition between the preS1 sequence of hepatitis B virus and human IgA in their binding to isolated normal human liver plasma membranes, suggesting molecular mimicry. Monoclonal and polyclonal antibodies raised against virus and IgA epitopes were used to detect and map immunological cross-reactivity to the virus sequence involved in liver cell binding. These findings suggest the existence of a common receptor or of closely related receptors for the attachment of HBV and IgA to human liver cells.
我们使用一种固相分析方法，证明了乙肝病毒的前S1序列与人IgA在与分离出的正常人肝细胞膜结合时存在特异性竞争，这表明存在分子模拟现象。针对病毒和IgA表位产生的单克隆抗体和多克隆抗体被用于检测和定位与肝细胞结合相关病毒序列的免疫交叉反应性。这些发现提示，乙肝病毒和IgA在附着于人类肝细胞时存在共同受体或密切相关的受体。
