钠离子牛磺胆酸共转运蛋白 NTCP 在乙型、丙型和丁型肝炎病毒生命周期中的功能作用。
The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses.
机构信息
Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, 3 Rue Koeberlé, 67000, Strasbourg, France.
Université de Strasbourg, 67000, Strasbourg, France.
出版信息
Cell Mol Life Sci. 2018 Nov;75(21):3895-3905. doi: 10.1007/s00018-018-2892-y. Epub 2018 Aug 10.
Abstract
Chronic hepatitis B, C and D virus (HBV, HCV and HDV) infections are a major cause of liver disease and cancer worldwide. Despite employing distinct replication strategies, the three viruses are exclusively hepatotropic, and therefore depend on hepatocyte-specific host factors. The sodium taurocholate co-transporting polypeptide (NTCP), a transmembrane protein highly expressed in human hepatocytes that mediates the transport of bile acids, plays a key role in HBV and HDV entry into hepatocytes. Recently, NTCP has been shown to modulate HCV infection of hepatocytes by regulating innate antiviral immune responses in the liver. Here, we review the current knowledge of the functional role and the molecular and cellular biology of NTCP in the life cycle of the three major hepatotropic viruses, highlight the impact of NTCP as an antiviral target and discuss future avenues of research.
摘要
慢性乙型肝炎、丙型肝炎和丁型肝炎病毒（HBV、HCV 和 HDV）感染是全球范围内肝脏疾病和癌症的主要病因。尽管采用了不同的复制策略，但这三种病毒都是嗜肝性的，因此依赖于肝细胞特异性的宿主因素。牛磺胆酸钠共转运多肽（NTCP）是一种在人肝细胞中高度表达的跨膜蛋白，介导胆汁酸的转运，在 HBV 和 HDV 进入肝细胞的过程中发挥关键作用。最近，NTCP 被证明可以通过调节肝脏中的先天抗病毒免疫反应来调节 HCV 感染肝细胞。在这里，我们综述了 NTCP 在三种主要嗜肝病毒生命周期中的功能作用和分子及细胞生物学的最新知识，强调了 NTCP 作为抗病毒靶点的重要性，并讨论了未来的研究方向。
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