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NnrA是完全毒力所必需的，并且调控多个布鲁氏菌的反硝化基因。

NnrA is required for full virulence and regulates several Brucella melitensis denitrification genes.

作者信息

Haine Valérie, Dozot Marie, Dornand Jacques, Letesson Jean-Jacques, De Bolle Xavier

机构信息

Unité de Recherche en Biologie Moléculaire (URBM), University of Namur (FUNDP), 61 rue de Bruxelles, B-5000 Namur, Belgium.

出版信息

J Bacteriol. 2006 Feb;188(4):1615-9. doi: 10.1128/JB.188.4.1615-1619.2006.

DOI:10.1128/JB.188.4.1615-1619.2006
PMID:16452445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1367225/
Abstract

We identified two regulators of denitrification genes in Brucella melitensis 16M: NarR, which regulates the nitrate reductase (nar) operon, and NnrA, which is involved in the expression of the last three reductases of the denitrification pathway (nirK, norB, and nosZ). NnrA is required for virulence in mice and for intracellular resistance to nitric oxide.

摘要

我们在布鲁氏菌16M中鉴定出两种反硝化基因的调节因子：NarR，它调节硝酸还原酶（nar）操纵子；以及NnrA，它参与反硝化途径中最后三种还原酶（nirK、norB和nosZ）的表达。NnrA是小鼠致病力以及细胞内对一氧化氮抗性所必需的。

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本文引用的文献

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Infect Immun. 2005 Sep;73(9):5578-86. doi: 10.1128/IAI.73.9.5578-5586.2005.
2
Phylogeny of the bacterial superfamily of Crp-Fnr transcription regulators: exploiting the metabolic spectrum by controlling alternative gene programs.Crp-Fnr转录调节因子细菌超家族的系统发育：通过控制替代基因程序利用代谢谱。
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Regulatory sequence analysis tools.调控序列分析工具。
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