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本文引用的文献

1
Systematic targeted mutagenesis of Brucella melitensis 16M reveals a major role for GntR regulators in the control of virulence.绵羊种布鲁氏菌16M株的系统性定向诱变揭示了GntR调控因子在毒力控制中的主要作用。
Infect Immun. 2005 Sep;73(9):5578-86. doi: 10.1128/IAI.73.9.5578-5586.2005.
2
A quorum-sensing regulator controls expression of both the type IV secretion system and the flagellar apparatus of Brucella melitensis.群体感应调节因子控制着布鲁氏菌IV型分泌系统和鞭毛装置的表达。
Cell Microbiol. 2005 Aug;7(8):1151-61. doi: 10.1111/j.1462-5822.2005.00543.x.
3
The sheathed flagellum of Brucella melitensis is involved in persistence in a murine model of infection.马尔他布鲁氏菌的鞘鞭毛与在小鼠感染模型中的持续性有关。
Cell Microbiol. 2005 May;7(5):687-98. doi: 10.1111/j.1462-5822.2005.00502.x.
4
Attenuated signature-tagged mutagenesis mutants of Brucella melitensis identified during the acute phase of infection in mice.在小鼠感染急性期鉴定出的减毒的布鲁氏菌标记诱变突变体。
Infect Immun. 2003 Dec;71(12):7053-60. doi: 10.1128/IAI.71.12.7053-7060.2003.
5
Brucella stationary-phase gene expression and virulence.布鲁氏菌的稳定期基因表达与毒力
Annu Rev Microbiol. 2003;57:57-76. doi: 10.1146/annurev.micro.57.030502.090803. Epub 2003 May 1.
6
Production of the type IV secretion system differs among Brucella species as revealed with VirB5- and VirB8-specific antisera.如用VirB5和VirB8特异性抗血清所显示的那样，布鲁氏菌属不同菌种IV型分泌系统的产生情况有所不同。
Infect Immun. 2003 Mar;71(3):1075-82. doi: 10.1128/IAI.71.3.1075-1082.2003.
7
The two-component system BvrR/BvrS essential for Brucella abortus virulence regulates the expression of outer membrane proteins with counterparts in members of the Rhizobiaceae.对布鲁氏菌毒力至关重要的双组分系统BvrR/BvrS调控外膜蛋白的表达，这些外膜蛋白在根瘤菌科成员中有对应物。
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12375-80. doi: 10.1073/pnas.192439399. Epub 2002 Sep 6.
8
Sigma B contributes to PrfA-mediated virulence in Listeria monocytogenes.西格玛B有助于单核细胞增生李斯特菌中由PrfA介导的毒力。
Infect Immun. 2002 Jul;70(7):3948-52. doi: 10.1128/IAI.70.7.3948-3952.2002.
9
A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis.根癌土壤杆菌VirB和百日咳博德特氏菌Ptl IV型分泌系统的同源物对猪布鲁氏菌的细胞内存活至关重要。
Mol Microbiol. 1999 Sep;33(6):1210-20. doi: 10.1046/j.1365-2958.1999.01569.x.
10
Light-induced carotenogenesis in Myxococcus xanthus: light-dependent membrane sequestration of ECF sigma factor CarQ by anti-sigma factor CarR.黄色粘球菌中光诱导的类胡萝卜素生成：抗σ因子CarR对ECF σ因子CarQ的光依赖性膜隔离
Mol Microbiol. 1996 Jan;19(1):171-86. doi: 10.1046/j.1365-2958.1996.360888.x.

一种类RpoH热休克σ因子参与了布鲁氏菌16M菌株的应激反应和毒力。

An RpoH-like heat shock sigma factor is involved in stress response and virulence in Brucella melitensis 16M.

作者信息

Delory Marie, Hallez Régis, Letesson Jean-Jacques, De Bolle Xavier

机构信息

Research Unit in Molecular Biology, URBM, University of Namur, FUNDP, 61 rue de Bruxelles, 5000 Namur, Belgium.

出版信息

J Bacteriol. 2006 Nov;188(21):7707-10. doi: 10.1128/JB.00644-06. Epub 2006 Aug 25.

DOI:10.1128/JB.00644-06
PMID:16936018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1636281/
Abstract

B. melitensis 16M genome analysis revealed the presence of six putative sigma factor-encoding genes: rpoD, rpoH1, rpoH2, rpoE1, rpoE2, and rpoN. We mutated all these genes except rpoD. Phenotypic analysis of the mutants reveals that a strain carrying an rpoH2 null mutation (DeltarpoH2) is impaired for growth at 21 and 42 degrees C and shows increased sensitivity to hydrogen peroxide. Compared to the wild-type strain, the DeltarpoH2 mutant is attenuated in all virulence models tested. Three other null mutants (DeltarpoH1, DeltarpoE1, and DeltarpoE2 mutants) are also defective for survival in mice at 4 weeks postinfection. We also demonstrated that rpoH2 deletion strongly reduces the expression of two major virulence factors in B. melitensis, the type IV secretion system and the flagellum.

摘要

马尔他布鲁氏菌16M基因组分析显示存在六个假定的编码σ因子的基因：rpoD、rpoH1、rpoH2、rpoE1、rpoE2和rpoN。我们对除rpoD之外的所有这些基因进行了突变。对突变体的表型分析表明，携带rpoH2无效突变（ΔrpoH2）的菌株在21℃和42℃下生长受损，并且对过氧化氢的敏感性增加。与野生型菌株相比，ΔrpoH2突变体在所有测试的毒力模型中均减弱。其他三个无效突变体（ΔrpoH1、ΔrpoE1和ΔrpoE2突变体）在感染后4周的小鼠体内存活也存在缺陷。我们还证明，rpoH2缺失会强烈降低马尔他布鲁氏菌中两种主要毒力因子IV型分泌系统和鞭毛的表达。