Rothenbacher D, Bode G, Berg G, Knayer U, Gonser T, Adler G, Brenner H
Department of Epidemiology, University of Ulm, D-89069 Ulm, Germany.
J Infect Dis. 1999 Feb;179(2):398-402. doi: 10.1086/314595.
This study assessed the role of parental infection status in the transmission of Helicobacter pylori infection in a large population-based sample of preschool-aged children. The subjects, who lived in Ulm, Germany, and in two nearby communities, were screened for school fitness between January and July 1997. Their H. pylori infection status was determined by 13C-urea breath test. Of 1522 eligible children, 1221 (80.2%) participated in the study. Crude prevalence of H. pylori infection in children was 11.3% (95% confidence interval [CI], 9.5-13.3) and 36.4% in their parents (95% CI, 33.5-39.4). The crude odds ratio (OR) for H. pylori infection of children whose mothers were infected was 16.5 (95% CI, 8.9-30.8) and 7.9 after adjustment for potential confounders (95% CI, 4.0-15.7). The crude OR if the child's father was infected was 7.8 (95% CI, 2. 5-24.2) and 3.8 after adjustment for potential confounders (except maternal infection) (95% CI, 0.8-19.1). The results suggest that infected parents, especially infected mothers, may have a key role in transmission of H. pylori within families.
本研究在一个基于大样本人群的学龄前儿童样本中，评估了父母感染状况在幽门螺杆菌感染传播中的作用。研究对象居住在德国乌尔姆市及附近两个社区，于1997年1月至7月期间接受入学健康筛查。通过¹³C - 尿素呼气试验确定他们的幽门螺杆菌感染状况。在1522名符合条件的儿童中，1221名（80.2%）参与了研究。儿童幽门螺杆菌感染的粗患病率为11.3%（95%置信区间[CI]，9.5 - 13.3），其父母的粗患病率为36.4%（95% CI，33.5 - 39.4）。母亲感染的儿童幽门螺杆菌感染的粗比值比（OR）为16.5（95% CI，8.9 - 30.8），在对潜在混杂因素进行调整后为7.9（95% CI，4.0 - 15.7）。若儿童的父亲感染，粗OR为7.8（95% CI，2.5 - 24.2），在对潜在混杂因素（母亲感染除外）进行调整后为3.8（95% CI，0.8 - 19.1）。结果表明，受感染的父母，尤其是受感染的母亲，可能在家庭内幽门螺杆菌的传播中起关键作用。
