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Kinetic and cross-linking studies indicate different receptors for endothelins and sarafotoxins in the ileum and cerebellum.

作者信息

Galron R, Bdolah A, Kochva E, Wollberg Z, Kloog Y, Sokolovsky M

机构信息

Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel.

出版信息

FEBS Lett. 1991 May 20;283(1):11-4. doi: 10.1016/0014-5793(91)80542-b.

DOI:10.1016/0014-5793(91)80542-b
PMID:1645289
Abstract

Kinetics of ligand/receptor interactions using ET-1, ET-3 and SRTX-b were studied and cross-linking experiments carried out in guinea pig ileum and rat cerebellar preparations. Dissociation studies indicate that the two regions are characterized by different receptor subtypes and different modes of ligand binding. Autoradiographic patterns obtained following cross-linking of ET-1 and ET-3 to the different tissues support these conclusions.

摘要

相似文献

1
Kinetic and cross-linking studies indicate different receptors for endothelins and sarafotoxins in the ileum and cerebellum.
FEBS Lett. 1991 May 20;283(1):11-4. doi: 10.1016/0014-5793(91)80542-b.
2
Endothelin/sarafotoxin receptor heterogeneity: evidence for different glycosylation in receptors from different tissues.内皮素/铃蟾毒素受体异质性：来自不同组织的受体中存在不同糖基化的证据。
Biochem Biophys Res Commun. 1991 Aug 15;178(3):921-6. doi: 10.1016/0006-291x(91)90979-h.
3
Cross-linking of endothelin 1 and endothelin 3 to rat brain membranes: identification of the putative receptor(s).内皮素1和内皮素3与大鼠脑膜的交联：推定受体的鉴定。
Biochemistry. 1990 Jul 10;29(27):6415-8. doi: 10.1021/bi00479a012.
4
Structure-function relationships of endothelins, sarafotoxins, and their receptor subtypes.内皮素、萨拉托毒素及其受体亚型的结构-功能关系。
J Neurochem. 1992 Sep;59(3):809-21. doi: 10.1111/j.1471-4159.1992.tb08318.x.
5
Endothelins and sarafotoxins: physiological regulation, receptor subtypes and transmembrane signaling.
Trends Biochem Sci. 1991 Jul;16(7):261-4. doi: 10.1016/0968-0004(91)90100-a.
6
In vitro autoradiographic endothelin-1 binding sites and sarafotoxin S6B binding sites in rat tissues.大鼠组织中内皮素-1结合位点和蛙皮素S6B结合位点的体外放射自显影研究
Clin Exp Pharmacol Physiol. 1991 Jul;18(7):509-15. doi: 10.1111/j.1440-1681.1991.tb01485.x.
7
Direct evidence for multiple endothelin receptors.
Biochemistry. 1991 May 28;30(21):5325-7. doi: 10.1021/bi00235a028.
8
Functional endothelin/sarafotoxin receptors in the rat uterus.大鼠子宫中的功能性内皮素/尾加压素受体
Biochem Biophys Res Commun. 1989 Aug 15;162(3):952-7. doi: 10.1016/0006-291x(89)90765-1.
9
Similarities in mode and sites of action of sarafotoxins and endothelins.
Trends Pharmacol Sci. 1989 Jun;10(6):212-4. doi: 10.1016/0165-6147(89)90261-7.
10
Functional endothelin/sarafotoxin receptors in rat heart myocytes: structure-activity relationships and receptor subtypes.大鼠心肌细胞中的功能性内皮素/铃蟾肽受体：构效关系与受体亚型
Biochem Biophys Res Commun. 1989 Sep 15;163(2):936-43. doi: 10.1016/0006-291x(89)92312-7.

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